Mechanisms of Brain-Heart Injury of Post-Intracranial Hemorrhage

Last updated: March 29, 2025
Sponsor: Beijing Tiantan Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Heart Failure

Chest Pain

Circulation Disorders

Treatment

Multi-disciplinary assessment

Clinical Study ID

NCT06906432
BHI2024
  • Ages 18-80
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Intracranial hemorrhage is a condition characterized by high mortality rates and suboptimal functional outcomes. It precipitates both direct brain injury and subsequent secondary injuries, including delayed cerebral ischemia, brain edema, and hydrocephalus. Complications such as cardiac injury may also arise, categorizing them within the cerebrocardiac syndrome (CCS). The clinical spectrum of CCS encompasses acute myocardial injury, acute coronary syndrome, left ventricular systolic and diastolic dysfunction, cardiac arrhythmias, and sudden cardiac death, all of which are associated with increased mortality and deterioration in patient status. The precise pathophysiological mechanisms underlying both cerebral and cardiac injuries remain enigmatic, and the implications for diagnosis and therapeutic strategies are yet to be fully explored.

In this study, we propose to enroll patients with intracranial hemorrhage who will undergo conventional treatment and comprehensive multidisciplinary evaluations. Our observational research is grounded in a multimodal omics and imaging approach, aimed at investigating both local and systemic injuries subsequent to intracranial hemorrhage. This comprehensive strategy is intended to facilitate precise diagnosis, risk stratification, and clinical decision-making, while also shedding light on the pathophysiological mechanisms involved.

The primary objectives of this research are to address the following key questions:

  • [Question 1] What are the pathophysiological mechanisms underlying cardiac injury in patients with intracranial hemorrhage?

  • [Question 2] What are the pathophysiological mechanisms responsible for early and delayed brain injuries following intracranial hemorrhage?"

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Patients aged 18 years or older at the time of enrollment.

  2. Acute intracranial hemorrhage confirmed by neuroimaging (CT, MRI，CTA, MRA, or DSA)within 48 hours of symptom onset.

  3. Ability to provide informed consent or have a legally authorized representativewilling to consent on their behalf.

Exclusion

Exclusion Criteria:

  1. Patients who refuse to participate in the study or cannot provide informed consent.

  2. Patients with a history of significant cardiovascular disease, including myocardialinfarction, heart failure, or arrhythmias, unless stable and well-controlled.

  3. Patients who have undergone cardiac bypass surgery, stent placement, or othercardiovascular interventions within the past 6 months.

  4. Patients with active brain tumors, ischemic stroke within 3 months or a history ofprevious brain injury that could confound the study findings.

  5. Patients with active malignant disease, severe inflammatory or infectious disease,or those who have undergone surgery for any reason within the past 3 months.

  6. Patients with any condition that, in the opinion of the investigator, would make itunsafe or impractical to participate in the study.

Study Design

Total Participants: 1000
Treatment Group(s): 1
Primary Treatment: Multi-disciplinary assessment
Phase:
Study Start date:
August 01, 2024
Estimated Completion Date:
December 01, 2036

Connect with a study center

  • Beijing Tiantan Hospital Affiliated to Capital Medical University

    Beijing, Beijing 100070
    China

    Active - Recruiting

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