Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of Migraines

Last updated: April 23, 2025
Sponsor: Wake Forest University Health Sciences
Overall Status: Active - Not Recruiting

Phase

3

Condition

Headaches

Oral Facial Pain

Chronic Pain

Treatment

Placebo

Magnesium

Clinical Study ID

NCT06904287
IRB00127959
  • Ages > 18
  • All Genders

Study Summary

The purpose of this research study is to find out if using magnesium in addition to prochlorperazine will help reduce your migraine pain.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age ≥ 18 years or older

  • Able to provide informed consent

  • English speaking

  • Primary diagnosis of migraine. Patient with a previous diagnosis of migraine, whoexperience headaches with typical migraine features (e.g at least 2-3 of thefollowing: recurrent, unilateral, pounding or throbbing in nature, associated withnausea), AND with a clinical exclusion of migraine mimics

Exclusion

Exclusion Criteria:

  • Pregnancy defined as a positive urine HCG

  • Allergy or sensitivity to study drug

  • Stated history of renal insufficiency

  • Documented history of myasthenia gravis

  • Consumption of study drug within 48 hours prior to enrollment

  • Previously enrolled in this trial during a different patient encounter

Study Design

Total Participants: 100
Treatment Group(s): 2
Primary Treatment: Placebo
Phase: 3
Study Start date:
August 01, 2025
Estimated Completion Date:
June 30, 2027

Study Description

The purpose of this prospective, randomized, double-blinded study is to compare the relative efficacy and safety of intravenous magnesium in conjunction with intravenous prochlorperazine in the treatment of migraines. Participants will be patients presenting to the Emergency Department with primary diagnosis of migraine.

Connect with a study center

  • Advocate Christ Medical Center Emergency Department

    Oak Lawn, Illinois 60453
    United States

    Site Not Available

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