PRevalence Of Transient Global Amnesia in Obstructive Sleep Apnea Syndrome

Last updated: March 24, 2025
Sponsor: University Hospital, Strasbourg, France
Overall Status: Active - Recruiting

Phase

N/A

Condition

Memory Loss

Memory Problems

Sleep Apnea Syndromes

Treatment

N/A

Clinical Study ID

NCT06903026
8781
  • Ages > 18
  • All Genders

Study Summary

Amnesic stroke is an amnestic syndrome lasting less than 24 hours characterized by the occurrence of anterograde amnesia often associated with retrograde amnesia, the pathophysiology of which is still poorly understood at present. A recent study on a small sample size (N=29) highlighted an association between obstructive sleep apnea syndrome and amnesic stroke. Our study seeks to confirm or refute these results on a larger cohort (N=200-250). A better understanding of the pathophysiological processes involved would open up new therapeutic avenues.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adult patients seen for consultation in the Neuropsychology Department of StrasbourgUniversity Hospital between March 1, 2015 and December 31, 2021 following an episodeof amnestic stroke meeting the Hodges and Warlow criteria:

  • The stroke must have been documented and reported by a competent witness presentduring the stroke.

  • Anterograde amnesia during the stroke.

  • Absence of vigilance, personality, and cognitive disorders other than memorydisorders (aphasia, apraxia, etc.).

  • Absence of focal neurological symptoms during the episode and its aftermath.

  • Absence of epileptic manifestations.

  • Resolution of the episode in less than 24 hours.

  • Exclusion of patients with a history of recent head trauma or active epilepsy (undergoing regular treatment or having experienced a seizure in the last 2 years).

  • Subjects who have not expressed opposition to the reuse of their data for scientificresearch purposes.

Exclusion

Exclusion Criteria:

  • Patients who have expressed opposition to the retrospective reuse of their data forscientific research purposes.

  • Patients with active epilepsy

  • Patients with recent head trauma

  • Patients with an MMS < or equal to 25

  • Subject under guardianship or curatorship

  • Subject under judicial protection

Study Design

Total Participants: 250
Study Start date:
March 17, 2023
Estimated Completion Date:
December 31, 2025

Connect with a study center

  • Service de Neurologie - CHU de Strasbourg - France

    Strasbourg, 67091
    France

    Active - Recruiting

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