Magnesium-L-Threonate for Sleep Quality Post-Arthroplasty

Inclusion Criteria:

• Patients undergoing primary total knee or hip arthroplasty at the University ofMiami Hospital

• Patients > 18 years of age

• Subjects must be capable of providing informed consent

• English or Spanish-speaking

Exclusion Criteria:

• Previous total joint arthroplasty at the surgical site

• History of sleeping disorders, including narcolepsy, sleep apnea, insomnia,parasomnias, and restless leg syndrome.

• History of Complex Regional Pain Syndrome in ipsilateral extremity

• History of demyelinating disorder or neurologic deficit in the affected extremity

• History of psychiatric disorders that could impact sleep, such as untreateddepression, bipolar disorder, or schizophrenia.

• Participants taking medications known to cause significant sedation or insomnia.

• Pregnant or breastfeeding

• Being treated for a diagnosis other than primary osteoarthritis (e.g. pelvic/femurfracture)

• Patients with known substance use disorder within 6 months of surgery

• Liver Failure, via clinical diagnosis or international normalized ratio greater than 1.5 or Prothrombin time greater than 40

• Chronic Kidney Disease or glomerular filtration rate less than 30 mL/min