A Study of Carbamazepine (CBZ) and MK-8527 in Healthy Adult Participants (MK-8527-012)

Inclusion Criteria:

Inclusion criteria include, but are not limited to:

• Is a healthy, adult, male or female of non-childbearing potential only, 18-55 yearsof age, inclusive

• Is a continuous non-smoker who has not used nicotine- and tobacco-containingproducts for at least 3 months prior

Exclusion Criteria:

Exclusion criteria include, but are not limited to:

• Has a history or presence of:

• Seizures (except for febrile seizure), or is at an increased risk for seizures

• Family history of severe dermatologic reactions including toxic epidermalnecrolysis and Stevens-Johnson syndrome

• Clinically meaningful hematologic diseases, bone marrow disorders, orhematologic adverse reactions to other medications

• Depression, unusual changes in mood or behavior or suicidal thoughts orbehavior

• Hypersensitivity reaction to anticonvulsant therapy (including phenytoin,primidone, and phenobarbital)

• Clinically significant eye disease

• Cardiac conduction disturbance, including second-and third-degreeatrioventricular heart block

• Shown to carry or be positive for HLA-A11:01, HLA-A31:01, HLA-B15:02,HLA-B15:08, HLA-B15:11, HLA-B15:21, HLA-B15:30, or HLA-B15:31 alleles.