Phase
Condition
N/ATreatment
Nipple Sparing Mastectomy
Total (Simple) Mastectomy
Skin-Sparing Mastectomy (SSM)
Clinical Study ID
Ages 18-90 Female
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Assigned female sex at birth
Age 18 years or older
Confirmed GPV in BRCA1, BRCA2, PALB2, TP53, CDH1 or PTEN identified onpre-symptomatic genetic testing
Exclusion
Exclusion Criteria:
History of breast cancer prior to genetic testing
History of ovarian cancer prior to genetic testing
History of bilateral mastectomy performed prior to genetic testing
Presence of a variant of uncertain significance (VUS) in the absence of another GPVin BRCA1, BRCA2, PALB2, TP53, CDH1 or PTEN.
Study Design
Connect with a study center
University of Melbourne, Peter MacCallum Cancer Center
Melbourne,
AustraliaSite Not Available
Ziekenhuis Aan de Stroom
Antwerpen, 2030
BelgiumSite Not Available
University of Calgary
Calgary, Alberta T2N 4N1
CanadaActive - Recruiting
Hamilton Health Sciences
Hamilton, Ontario L8L 2X2
CanadaActive - Recruiting
Women's College Hospital, University of Toronto
Toronto, Ontario
CanadaSite Not Available
Jewish General Hospital
Montreal, Quebec H3T1E2
CanadaActive - Recruiting
CHU de Quebec Université laval
Quebec, G1S 4L8
CanadaActive - Recruiting
Champalimaud Foundation, University of Lisbon
Lisbon,
PortugalSite Not Available
Yale University
New Haven, Connecticut 06510
United StatesActive - Recruiting
Brigham and Women's Hospital - Dana-Farber Brigham Cancer Center
Boston, Massachusetts 02115
United StatesSite Not Available
Memorial Sloan Kettering Cancer Center (MSKCC)
New York City, New York 10065
United StatesSite Not Available
University of Pennsylvania
Philadelphia, Pennsylvania 19104-6205
United StatesActive - Recruiting
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