A Single-arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Selected Surgeries

Last updated: November 13, 2025
Sponsor: Vertex Pharmaceuticals Incorporated
Overall Status: Active - Not Recruiting

Phase

4

Condition

Pain

Acute Pain

Treatment

Suzetrigine

Clinical Study ID

NCT06887959
VX24-548-108
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to evaluate the effectiveness, safety, and tolerability of SUZ for acute pain after laparoscopic procedures of the intraperitoneal or retroperitoneal cavities or arthroscopic orthopedic procedures.

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

  • Body mass index (BMI) of greater than or equal to (≥) 18.0 to less than or equal to (≤) 40.0 kilogram per meter square (kg/m^2)

  • Scheduled to undergo a procedure that is in one of the following categories thatwould typically be treated with opioid therapy for at least 72 hours postoperativelysuch as

  • Laparoscopic intraperitoneal or retroperitoneal procedure

  • Arthroscopic orthopedic procedure

Exclusion

Key Exclusion Criteria:

-Participated in previous study with Suzetrigine or received Journavx

Other protocol defined Inclusion/Exclusion criteria will apply.

Study Design

Total Participants: 47
Treatment Group(s): 1
Primary Treatment: Suzetrigine
Phase: 4
Study Start date:
March 27, 2025
Estimated Completion Date:
November 10, 2025

Connect with a study center

  • Scottsdale Clinical Trials

    Scottsdale, Arizona 85260
    United States

    Site Not Available

  • Scottsdale Clinical Trials

    Scottsdale 5313457, Arizona 5551752 85260
    United States

    Site Not Available

  • Woodland International Research Group

    Little Rock, Arkansas 72211
    United States

    Site Not Available

  • Woodland International Research Group

    Little Rock 4119403, Arkansas 4099753 72211
    United States

    Site Not Available

  • Gulfcoast Research Institute

    Sarasota 4172131, Florida 4155751 34232
    United States

    Site Not Available

  • MedStar

    Baltimore, Maryland 21218
    United States

    Site Not Available

  • MedStar

    Baltimore 4347778, Maryland 4361885 21218
    United States

    Site Not Available

  • Oasis Clinical Research

    Las Vegas, Nevada 89121
    United States

    Site Not Available

  • Oasis Clinical Research

    Las Vegas 5506956, Nevada 5509151 89121
    United States

    Site Not Available

  • Cooper University HealthCare (CUH)

    Camden, New Jersey 08103
    United States

    Site Not Available

  • Cooper University HealthCare (CUH)

    Camden 4501018, New Jersey 5101760 08103
    United States

    Site Not Available

  • North Shore University Hospital - Anesthesiology

    Manhasset, New York 11030
    United States

    Site Not Available

  • North Shore University Hospital - Anesthesiology

    Manhasset 5125766, New York 5128638 11030
    United States

    Site Not Available

  • OrthoCarolina - Hip & Knee Center

    Charlotte, North Carolina 28207
    United States

    Site Not Available

  • Duke University Hospital - Anesthesiology

    Durham, North Carolina 27710
    United States

    Site Not Available

  • Eximia Research-Durham

    Durham, North Carolina 27704
    United States

    Active - Recruiting

  • West Clinical Research

    Morehead City, North Carolina 28557
    United States

    Site Not Available

  • Seaside Clinical Research Institute

    Wilmington, North Carolina 28412
    United States

    Site Not Available

  • OrthoCarolina - Hip & Knee Center

    Charlotte 4460243, North Carolina 4482348 28207
    United States

    Site Not Available

  • Duke University Hospital - Anesthesiology

    Durham 4464368, North Carolina 4482348 27710
    United States

    Site Not Available

  • Eximia Research-Durham

    Durham 4464368, North Carolina 4482348 27704
    United States

    Site Not Available

  • West Clinical Research

    Morehead City 4480153, North Carolina 4482348 28557
    United States

    Site Not Available

  • Seaside Clinical Research Institute

    Wilmington 4499379, North Carolina 4482348 28412
    United States

    Site Not Available

  • UH Cleveland Medical Center - Anesthesiology

    Cleveland, Ohio 44106
    United States

    Site Not Available

  • UH Cleveland Medical Center - Anesthesiology

    Cleveland 5150529, Ohio 5165418 44106
    United States

    Site Not Available

  • University of Tennessee Medical Center - Anethesiology

    Knoxville, Tennessee 37920
    United States

    Site Not Available

  • University of Tennessee Medical Center - Anethesiology

    Knoxville 4634946, Tennessee 4662168 37920
    United States

    Site Not Available

  • HD Research LLC | First Surgical Hospital

    Bellaire, Texas 77401
    United States

    Site Not Available

  • Memorial Hermann Village

    Houston, Texas 77043
    United States

    Site Not Available

  • HD Research LLC | First Surgical Hospital

    Bellaire 4673353, Texas 4736286 77401
    United States

    Site Not Available

  • Memorial Hermann Village

    Houston 4699066, Texas 4736286 77043
    United States

    Site Not Available

  • Tidewater Clinical Research

    Norfolk, Virginia 23502
    United States

    Site Not Available

  • Tidewater Clinical Research

    Norfolk 4776222, Virginia 6254928 23502
    United States

    Site Not Available

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