JUPITER 4.0 - Risk Factors for Failure of Isolated Medial Patellofemoral Ligament Reconstruction

Last updated: March 12, 2025
Sponsor: Hospital for Special Surgery, New York
Overall Status: Active - Recruiting

Phase

N/A

Condition

Joint Injuries

Treatment

Medial Patellofemoral Ligament (MPFL) Reconstruction

Clinical Study ID

NCT06883396
2022-0649
  • Ages 10-35
  • All Genders

Study Summary

The goal of this observational study is to learn about the outcomes of medial patellofemoral ligament (MPFL) reconstruction for the treatment of recurrent patellar instability. The main questions it aims to answer are:

  • What are the risk factors for recurrent patellar instability after MPFL reconstruction?

  • What functional outcomes do patients report after MPFL reconstruction?

Participants undergoing MPFL reconstruction will answer survey questions about their knee and activity level 1 year and 2 years after surgery.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • 10-35 years old

  • Recurrent patellar instability with at least one episode defined as either (1) adislocated patella requiring reduction in the emergency department or (2) aconvincing history for dislocation, associated with full giving way, and thefollowing physical findings: (a) hemarthrosis or effusion, (b) tenderness along themedial retinaculum, and (c) apprehension when laterally directed force was appliedto the patella or (3) MRI-documented dislocation with associated bone bruises

Exclusion

Exclusion Criteria:

  • Previous ipsilateral knee surgery

  • Obligatory/fixed/habitual patella dislocation or subluxation

  • Unloadable inferior or lateral chondral damage on the patella that would require atibial tubercle transfer for unloading purposes

  • Pathologic tibiofemoral instability

Study Design

Total Participants: 850
Treatment Group(s): 1
Primary Treatment: Medial Patellofemoral Ligament (MPFL) Reconstruction
Phase:
Study Start date:
January 01, 2023
Estimated Completion Date:
December 31, 2027

Study Description

The JUPITER group consists of high-volume patellofemoral surgeons across the United States, and was organized to facilitate the collection of clinical and radiographic outcomes following surgical and non-surgical treatment of patellar instability. With this study (JUPITER 4.0), the group aims to prospectively enroll a new cohort of consecutive patients with recurrent patellar instability that would undergo isolated MPFL reconstruction regardless of radiographic measurements or anatomic risk factors to address two specific aims - 1) what patient, injury, and surgical factors lead to recurrent instability following isolated MPFL reconstruction and 2) the creation of an instability severity index score, with the long-term objective of identifying preoperatively, patients with a high risk of failure of an isolated MPFL reconstruction who may be better served with concomitant bony procedure.

Connect with a study center

  • Stanford University

    Redwood City, California 94063
    United States

    Active - Recruiting

  • University of Florida

    Gainesville, Florida 32607
    United States

    Active - Recruiting

  • Midwest Orthopaedics at Rush

    Chicago, Illinois 60612
    United States

    Active - Recruiting

  • University of Iowa

    Iowa City, Iowa 52242
    United States

    Active - Recruiting

  • Boston Children's Hospital

    Boston, Massachusetts 02115
    United States

    Active - Recruiting

  • Massachusetts General Hospital

    Boston, Massachusetts 02114
    United States

    Active - Recruiting

  • Mayo Clinic

    Rochester, Minnesota 55905
    United States

    Site Not Available

  • Hospital for Special Surgery

    New York, New York 10021
    United States

    Active - Recruiting

  • Mount Sinai

    New York, New York 10012
    United States

    Site Not Available

  • NYU Langone Health

    New York, New York 10016
    United States

    Active - Recruiting

  • Duke Health

    Wake Forest, North Carolina 27587
    United States

    Active - Recruiting

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio 45229
    United States

    Active - Recruiting

  • Cleveland Clinic

    Cleveland, Ohio 44195
    United States

    Site Not Available

  • Ohio State University Wexler Medical Center

    Dublin, Ohio 43016
    United States

    Active - Recruiting

  • Oregon Health & Science University

    Portland, Oregon 97239
    United States

    Active - Recruiting

  • Scottish Rite for Children

    Dallas, Texas 75219
    United States

    Active - Recruiting

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