Neural Mechanisms of Dialectical Behavioral Therapy in Patients with Borderline Personality Disorder

Last updated: March 12, 2025
Sponsor: Masarykova Univerzita
Overall Status: Completed

Phase

N/A

Condition

Mood Disorders

Borderline Personality Disorder

Schizotypal Personality Disorder (Spd)

Treatment

Dialectical behavior therapy

Clinical Study ID

NCT06882330
NU20-04-00410
  • Ages > 16
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This research examines the behavioral and neural mechanisms of dialectical behavior therapy (DBT) effect in patients with borderline personality disorder (BPD).

Eligibility Criteria

Inclusion

BPD-DBT group:

Inclusion Criteria:

  • diagnosis of borderline personality disorder according to Diagnostic and StatisticalManual 5th Edition (DSM-5) criteria (rated by Structured Clinical Interview forDSM-5 for Personality Disorders, BPD section)

  • minimum age 16, informed consent of the patient

  • informed consent of patient's legal representative in case of patients under age 18

  • more than one self-injury incident and/or suicidal attempt in the past six months

Exclusion

Exclusion Criteria:

  • neurological disorder

  • comorbid affective disorder or schizophrenia-related disorder

  • intelligence quotient<70

  • contraindications for MRI measurement

  • pregnancy

  • body mass index under 15

BPD-C group:

Inclusion Criteria:

  • diagnosis of borderline personality disorder according to Diagnostic and StatisticalManual 5th Edition (DSM-5) criteria (rated by Structured Clinical Interview forDSM-5 for Personality Disorders, BPD section)

  • minimum age 16, informed consent of the patient

  • informed consent of patient's legal representative in case of patients under age 18

  • more than one self-injury incident and/or suicidal attempt in the past six months

Exclusion Criteria:

  • completing a DBT program or attending DBT-based therapy

  • neurological disorder

  • comorbid affective disorder or schizophrenia-related disorder

  • intelligence quotient<70

  • contraindications for MRI measurement

  • pregnancy

  • body mass index under 15

HC group:

Inclusion criteria:

  • minimum age 16, informed consent of the patient

  • informed consent of patient's legal representative in case of patients under age 18

Exclusion criteria:

  • mental health problems

  • history of self-injury or/and suicidal attempt

  • neurological disorder

  • intelligence quotient<70

  • contraindications for MRI measurement

  • pregnancy

  • body mass index under 15

Study Design

Total Participants: 106
Treatment Group(s): 1
Primary Treatment: Dialectical behavior therapy
Phase:
Study Start date:
August 27, 2020
Estimated Completion Date:
August 15, 2023

Study Description

This project aims to evaluate the behavioral and neural mechanisms of dialectical behavior therapy (DBT) effect in patients with borderline personality disorder (BPD). The project includes three subject groups: patients with BPD undergoing the DBT program (BPD-DBT), control patients with BPD on the waiting list for the program (BPD-control), and healthy controls (HC). Patients in the BPD-DBT group undergo a 24-week DBT program in an outpatient setting. All participants undergo a test battery comprising of self-report measures, clinical evaluation and fMRI and EEG measurement in the week before the DBT program beginning (T1), after 24 weeks (follow-up, T3), and at 24 weeks after T3 (follow-up, T4). The BPD-DBT group undergoes another assessment at T2 (after 12 weeks) to monitor selected symptoms during the DBT program by a short set of questionnaires.

Connect with a study center

  • University Hospital Brno and Faculty of Medicine, Masaryk University

    Brno, 62500
    Czech Republic

    Site Not Available

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