Longitudinal Study to Investigate Different Transcranial Electrical Stimulation

Phase

N/A

Condition

Dementia

Treatment

50 Hz Transcranial Alternating Current Stimulation (tACS)

Transcranial Direct Current Stimulation (tDCS)

30 Hz Transcranial Alternating Current Stimulation (tACS)

Clinical Study ID

NCT06877312

B2021:089

Ages 50-95
All Genders

Study Summary

This research investigates the effect of different frequencies of tACS (0 Hz, 30 Hz, 50 Hz, 70 Hz, 90 Hz) and tRNS with cognitive exercises in a regimen protocol of weeks, everyday. The study design is a longitudinal study design in which participants receive different tES randomly ordered. Treatments occur for 4 weeks, then 12 weeks of no treatment (wash-out period), repeated for each tES treatment type. Participants have the option of having their choice of music in the background while they perform cognitive exercise.

Eligibility Criteria

Inclusion

Inclusion Criteria:

ability to read, write and speak English fluently
MoCA score between 5 and 24

Exclusion

Exclusion Criteria:

Being diagnosed with Parkinson's, Parkinsonian dementia, Huntington disease, speechsignificant aphasia and intellectual disability, major depression/anxiety, bipolardisorder, schizophrenia or any other major mood disorder.
Having a Hhistory of epileptic seizures or epilepsy
Inability to adequately communicate in English
Impaired vision or hearing severe enough to impair performance in cognitive tests
Current substance abuse disorder
Currently participating in another therapeutic study for dementia
Plan to change the medication during any treatment period (5 weeks including thepre-post assessments)

Study Design

50 Hz Transcranial Alternating Current Stimulation (tACS)

October 09, 2024

December 31, 2033

Study Description

This research will investigate the effect of applying transcranial electrical stimulation (tES) with different parameters when paired with cognitive exercises with optional background music on older adults in a longitudinal study. In addition, the investigators will investigate and explore novel technological methods not only to monitor the plausible changes due to intervention. Since most technological intervention on dementia have a demanding and costly protocol, it would be of great interest to personalized optimum treatment strategy. The investigators will use Egocentric Spatial Assessment using our Virtual Reality Navigation (VRN) and functional near infrared spectroscopy (fNIRS) measurements and analysis to develop the monitoring technologies. VRN measures how people orient themselves in a non-familiar environment; the investigators hypothesize it is deteriorated significantly in Alzheimer's even at its onset. fNIRS measures oxygenated and deoxygenated blood flow to the brain and it may help to understand neuronal changes due to intervention.

Connect with a study center

Riverview Health Centre
Winnipeg, Manitoba R3L 2P4
Canada
Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.