A Study of (LY3527727) Pirtobrutinib in Participants With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma

Last updated: February 27, 2026
Sponsor: Eli Lilly and Company
Overall Status: Active - Recruiting

Phase

4

Condition

Hematologic Cancer

Marginal Zone Lymphoma

White Cell Disorders

Treatment

Pirtobrutinib

Clinical Study ID

NCT06876662
27289
2024-517760-29-00
J2N-MC-JZ01
J2N-MC-JZNY
  • Ages > 18
  • All Genders

Study Summary

Study J2N-MC-JZ01 (JZ01) is an individual-study appendix (ISA) under master protocol J2N-MC-JZNY, and represents participants from the completed originator study, clinical study LOXO-BTK-18001/J2N-OX-JZNA. Participants in the originator study will have the opportunity to continue their assigned study intervention or continue their follow-up visits by transitioning to this study. This study will evaluate the long-term safety and efficacy of pirtobrutinib.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Are currently enrolled and active in the originator study, LOXO-BTK-18001. Aparticipant is considered active in the study if they are:

  • receiving study intervention

  • in the short-term follow-up period, or

  • in the long-term follow-up period

Exclusion

Exclusion Criteria:

  • Were a participant in the Phase 1b cohort of Study LOXO-BTK-18001

Study Design

Total Participants: 279
Treatment Group(s): 1
Primary Treatment: Pirtobrutinib
Phase: 4
Study Start date:
May 20, 2025
Estimated Completion Date:
December 31, 2032

Connect with a study center

  • Flinders Medical Centre

    Adelaide, South Australia 5042
    Australia

    Site Not Available

  • Peter MacCallum Cancer Centre

    Melbourne, Victoria 3000
    Australia

    Site Not Available

  • Flinders Medical Centre

    Adelaide 2078025, 5042
    Australia

    Active - Recruiting

  • Peter MacCallum Cancer Centre

    Melbourne 2158177, 3000
    Australia

    Completed

  • Linear Clinical Research

    Victoria, 3000
    Australia

    Site Not Available

  • CHU de Nantes - Hotel Dieu

    Nantes Cedex 1, Loire Atlantique 44093
    France

    Site Not Available

  • CHU de Nantes - Hotel Dieu

    Nantes 2990969, 44093
    France

    Active - Recruiting

  • IRCCS-AOU di Bologna-Policlinico S.Orsola-Malpighi

    Bologna, 40138
    Italy

    Site Not Available

  • IRCCS-AOU di Bologna-Policlinico S.Orsola-Malpighi

    Bologna 3181928, 40138
    Italy

    Completed

  • Ospedale San Raffaele

    Milan 6951411, 20132
    Italy

    Active - Recruiting

  • Ospedale San Raffaele

    Milano, 20132
    Italy

    Site Not Available

  • Nagoya Medical Center

    Nagoya-shi, Aichi-Ken 4600001
    Japan

    Site Not Available

  • Tokai University Hospital- Isehara Campus

    Isehara, Kanagawa 259-1193
    Japan

    Site Not Available

  • Nagoya Medical Center

    Aichi-Ken, 4600001
    Japan

    Site Not Available

  • National Cancer Center Hospital

    Cho-ku, 104-0045
    Japan

    Completed

  • National Hospital Organization Kyushu Cancer Center

    Fukuoka, 811-1395
    Japan

    Site Not Available

  • National Hospital Organization Kyushu Cancer Center

    Fukuoka 1863967, 811-1395
    Japan

    Site Not Available

  • Tokai University Hospital- Isehara Campus

    Isehara 1861449, 259-1193
    Japan

    Site Not Available

  • Tohoku University Hospital

    Miyagi-Ken, 9808574
    Japan

    Site Not Available

  • Hokkaido University Hospital

    Sapporo 2128295, 060-8648
    Japan

    Site Not Available

  • Hokkaido University Hospital

    Sapporoshi, 060-8648
    Japan

    Site Not Available

  • Seoul National University Hospital

    Seoul, Korea 03080
    Korea, Republic of

    Site Not Available

  • Samsung Medical Center

    Seoul, 06351
    Korea, Republic of

    Site Not Available

  • Pratia MCM Krakow

    Krakow, 30727
    Poland

    Site Not Available

  • Pratia MCM Krakow

    Krakow 3094802, 30727
    Poland

    Active - Recruiting

  • Instytut Hermatologii I Transfuzjologii

    Warsaw 756135, 02-776
    Poland

    Active - Recruiting

  • Instytut Hermatologii I Transfuzjologii

    Warszawa, 02-776
    Poland

    Site Not Available

  • Seoul National University Hospital

    Seoul 1835848, 03080
    South Korea

    Active - Recruiting

  • Derriford Hospital

    Plymouth, Devon PL6 8DH
    United Kingdom

    Site Not Available

  • Churchill Hospital

    Oxford, Oxfordshire OX3 7LE
    United Kingdom

    Site Not Available

  • St James's University Hospital

    Leeds, West Yorkshire LS9 7TF
    United Kingdom

    Site Not Available

  • St James's University Hospital

    Leeds 2644688, LS9 7TF
    United Kingdom

    Active - Recruiting

  • Churchill Hospital

    Oxford 2640729, OX3 7LE
    United Kingdom

    Active - Recruiting

  • Derriford Hospital

    Plymouth 2640194, PL6 8DH
    United Kingdom

    Active - Recruiting

  • Sylvester Comprehensive Cancer Center

    Miami, Florida 33136-1002
    United States

    Site Not Available

  • Florida Cancer Specialists

    Sarasota, Florida 34232-6422
    United States

    Site Not Available

  • Sylvester Comprehensive Cancer Center

    Miami 4164138, Florida 4155751 33136-1002
    United States

    Active - Recruiting

  • Florida Cancer Specialists

    Sarasota 4172131, Florida 4155751 34232-6422
    United States

    Active - Recruiting

  • The Emory Clinic

    Atlanta, Georgia 30322-1013
    United States

    Site Not Available

  • The Emory Clinic

    Atlanta 4180439, Georgia 4197000 30322-1013
    United States

    Active - Recruiting

  • Northwestern University

    Chicago, Illinois 60611-3013
    United States

    Site Not Available

  • Northwestern University

    Chicago 4887398, Illinois 4896861 60611-3013
    United States

    Active - Recruiting

  • Dana-Farber Cancer Institute

    Boston, Massachusetts 02115
    United States

    Site Not Available

  • Dana-Farber Cancer Institute

    Boston 4930956, Massachusetts 6254926 02115
    United States

    Active - Recruiting

  • Mayo Clinic- Minnesota

    Rochester, Minnesota 55905
    United States

    Site Not Available

  • Mayo Clinic- Minnesota

    Rochester 5043473, Minnesota 5037779 55905
    United States

    Active - Recruiting

  • University Of Nebraska Medical Center

    Omaha, Nebraska 69198
    United States

    Site Not Available

  • University Of Nebraska Medical Center

    Omaha 5074472, Nebraska 5073708 69198
    United States

    Active - Recruiting

  • Cayuga Cancer Center

    Ithaca, New York 14850
    United States

    Site Not Available

  • Northwell Health

    Lake Success, New York 11042-1118
    United States

    Site Not Available

  • Memorial Sloan-Kettering Cancer Center (MSKCC) - New York

    New York, New York 10065-6007
    United States

    Site Not Available

  • Cayuga Cancer Center

    Ithaca 5122432, New York 5128638 14850
    United States

    Site Not Available

  • Northwell Health

    Lake Success 5123853, New York 5128638 11042-1118
    United States

    Active - Recruiting

  • Memorial Sloan-Kettering Cancer Center (MSKCC) - New York

    New York 5128581, New York 5128638 10065-6007
    United States

    Active - Recruiting

  • Duke University Medical Center

    Durham, North Carolina 27710-4000
    United States

    Site Not Available

  • Duke University Medical Center

    Durham 4464368, North Carolina 4482348 27710-4000
    United States

    Active - Recruiting

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio 43210-1063
    United States

    Site Not Available

  • Ohio State University Comprehensive Cancer Center

    Columbus 4509177, Ohio 5165418 43210-1063
    United States

    Active - Recruiting

  • University of Pennsylvania Hospital

    Philadelphia, Pennsylvania 19104
    United States

    Site Not Available

  • University of Pennsylvania Hospital

    Philadelphia 4560349, Pennsylvania 6254927 19104
    United States

    Active - Recruiting

  • Tennessee Oncology

    Nashville, Tennessee 37203-2659
    United States

    Site Not Available

  • Tennessee Oncology

    Nashville 4644585, Tennessee 4662168 37203-2659
    United States

    Active - Recruiting

  • University of Texas MD Anderson Cancer Center

    Houston, Texas 77030-4000
    United States

    Site Not Available

  • University of Texas MD Anderson Cancer Center

    Houston 4699066, Texas 4736286 77030-4000
    United States

    Active - Recruiting

  • Swedish Cancer Institute

    Seattle, Washington 98104-3588
    United States

    Site Not Available

  • Swedish Cancer Institute

    Seattle 5809844, Washington 5815135 98104-3588
    United States

    Active - Recruiting

  • Medical College of Wisconsin

    Milwaukee, Wisconsin 53226-3548
    United States

    Site Not Available

  • Medical College of Wisconsin

    Milwaukee 5263045, Wisconsin 5279468 53226-3548
    United States

    Active - Recruiting

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