A Single-arm, Open, Single-center Exploratory Study of Adebrelimab (SHR-1316) in Combination With Chemotherapy for the Perioperative Treatment of Locally Advanced Resectable Esophageal Squamous Carcinoma

Inclusion Criteria:

1. Aged 18-75 years old, regardless of gender；

2. Surgically resectable locally advanced squamous cell carcinoma of the esophagusconfirmed by histology or cytology (pre-treatment clinical stage cT1b-cT2, N+ orcT3-cT4a, ANY N according to the 8th edition of AJCC staging);

3. Presence of measurable and/or non-measurable lesions as defined by the criteria forevaluating the efficacy of solid tumors (RECIST v1.1);

4. No prior antitumor therapy for esophageal cancer, including chemotherapy,radiotherapy (including planned radiotherapy during the study period), hormonetherapy, and immunotherapy;

5. ECOG PS 0 to 1 point;

6. No contraindication to surgery as evaluated by various organ function tests;

7. Prior to treatment, the following laboratory tests to confirm that bone marrow,liver and kidney function meet the requirements for participation in the study (requiring no blood transfusion or use of hematopoietic stimulating factors (including G-CSF, GM-CSF , EPO, and TPO, etc.) within 14 days prior to screening):

• Hemoglobin ≥ 90 g/L;

• White blood cell count ≥ lower limit of laboratory normal;

• Absolute neutrophil count (ANC) ≥ 1.5 × 109/L;

• Platelet count ≥100×109/L;

• Total bilirubin ≤ 1.5 x upper limit of normal (ULN);

• Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 xULN;

• Prothrombin time ≤ 16 seconds and International Normalized Ratio (INR) ≤ 1.5 xULN;

• Creatinine ≤ 1.5 x ULN and Cr clearance ≥ 50 mL/min (calculated using theCockcroft-Gault formula);

8. Must understand and voluntarily sign an informed consent form.

Exclusion Criteria:

1. malignant tumors other than esophageal cancer within 5 years prior to enrollment (cured limited tumors are not excluded, including cervical carcinoma in situ, basalcell carcinoma of the skin, and carcinoma in situ of the prostate gland; patientswith prostate cancer who received hormone therapy and obtained DFS for more than 5years are not excluded)；

2. Comorbid serious cardiac and cerebrovascular diseases:

• Congestive heart failure, unstable angina, myocardial infarction, poorlycontrolled arrhythmia, or cerebrovascular accident of New York HeartAssociation (NYHA) class II or higher within 12 months prior to enrollment.

• Medication-uncontrolled hypertension (systolic blood pressure ≥150 mmHg and/ordiastolic blood pressure ≥100 mmHg) (based on the average of ≥2 measurements)

• Previous hypertensive crisis or hypertensive encephalopathy

3. Prior history of interstitial lung disease or pneumonia requiring steroid therapy atenrollment；

4. Have a blood-borne infectious disease, including, but not limited to, hepatitis Bvirus carrier, hepatitis C, syphilis, or HIV;

5. Previous severe allergy to chemotherapeutic agents (paclitaxel or carboplatin) or toany of the monoclonal antibodies;

6. Active autoimmune disease requiring systemic therapy (i.e., immunomodulatory drugs,corticosteroid drugs, or immunosuppressive drugs) within the past 2 years; however,alternative therapies (e.g., thyroxine, insulin, or physiologic corticosteroidreplacement therapy for adrenal or pituitary insufficiency) are not consideredsystemic and are permitted and enrollment is allowed;

7. Women during pregnancy;

8. Patients who, in the opinion of the investigator, are not suitable for participationin this study, based on a comprehensive assessment.