Single Cell Landscape of HBV-related Acute-on-chronic Liver Failure Patients

Phase

N/A

Condition

Liver Failure

Liver Disease

Primary Biliary Cholangitis

Treatment

N/A

Clinical Study ID

NCT06865859

KYLL-202310-036

Ages > 18
All Genders

Study Summary

This study aimed to profile the peripheral blood immune cells of patients with HBV related acute-on-chronic liver failure using single-cell RNA sequencing to reveal the immunopathological mechanisms of HBV related acute-on-chronic liver failure.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Acute liver failure is a well-defned medical emergency which is defned as a severe liver injury, leading to coagulation abnormality usually with an INR ≥ 1.5, and any degree of mental alteration (encephalopathy) in a patient without pre-existing liver disease and with an illness of up to 4 weeks duration

Exclusion

Exclusion Criteria:

Associated with other types of hepatitis virus infection or HIV infection, alcoholicliver disease, autoimmune liver disease, drug-induced liver injury; ② Suffering fromprimary liver cancer or severe heart, digestive, lung, kidney, neurological andpsychiatric diseases; ③ Patients with incomplete data and patients unable toparticipate in the experiment.

Study Design

November 01, 2023

May 31, 2025

Study Description

Acute-on-chronic liver failure (ACLF) is a complex clinical syndrome characterized by acute deterioration of liver function in patients with chronic liver disease, exhibiting liver and extrahepatic organ failure and a high short-term mortality. Immune imbalance plays an important role in the progression of HBV-related ACLF. Further investigation of the immune cell characteristics of HBV-related ACLF is helpful to understand its pathogenesis, and may provide reference for the effective therapeutic agent. Single-cell RNA sequencing (scRNA-seq) is the quantitative analysis of transcription at the single-cell level, which could provide systematic analyses of transcriptomic profiles, infer cell-cell interactions. This study will combine single cell transcriptomics and molecular biological experiment to elucidate the immunopathological cell states associated with HBV-related chronic liver disease vs. ACLF.

Connect with a study center

Qilu Hospital of Shandong University
Jinan, Shandong 250012
China
Active - Recruiting

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