Efficacy and Safety of Colorectal Anastomotic Leak Testing

Inclusion Criteria:

1. Patients diagnosed with colorectal cancer by pathology and scheduled for surgicaltreatment who meet the surgical indications.

2. Aged between 18 and 85 years.

3. American Society of Anesthesiologists (ASA) physical status classification is I -III.

4. The patient or his/her legal representative can understand and sign the informedconsent form and is willing to cooperate throughout the study process.

Exclusion Criteria:

1. Patients with preoperatively diagnosed anastomotic leak or other severe abdominalinfections.

2. Patients with severe cardiovascular and cerebrovascular diseases (such as recentmyocardial infarction, unstable angina pectoris, severe heart failure, acutecerebral infarction, etc.) who cannot tolerate surgery and related tests.

3. Patients with severely impaired liver and kidney function (liver function Child -Pugh classification C or above, creatinine clearance rate < 30 ml/min).

4. Patients with coagulation disorders (such as platelet count < 50×10⁹/L,international normalized ratio (INR) > 1.5, etc.) that cannot be corrected or arereceiving anticoagulant therapy that cannot be adjusted.

5. Patients with a history of abdominal radiotherapy or multiple abdominal surgeriesand severe abdominal adhesions that may affect the operation and detectionprocedures.

6. Patients with other malignant tumors who are receiving active anti-tumor treatmentsuch as radiotherapy and chemotherapy.

7. Patients with mental illness or cognitive impairment who cannot cooperate with thestudy process and follow-up.