Study of Targeted Therapies for the Treatment of Adult Participants With Active Psoriatic Arthritis

Inclusion Criteria:

• Participant is willing and able to comply with procedures required in the MasterProtocol and substudies.

• Participant has a documented clinical diagnosis of PsA with symptom onset at least 6months prior to the Screening Visit and fulfillment of the Classification Criteriafor Psoriatic Arthritis (CASPAR) at Screening Visit.

• Participant has active disease defined as greater than or equal to 3 tender joints (based on 68 joint count) and greater than or equal to 3 swollen joints (based on 66joint count) at both the Screening Visit and Baseline.

• Participant has active plaque PsO and/or a documented history of plaque PsO.

• Participant must demonstrate intolerance or inadequate response to 1 to 2 targetedtherapies (biologic or targeted synthetic disease-modifying antirheumatic drugs)approved for the treatment of PsA

Exclusion Criteria:

• Participants who have had major surgery performed within 12 weeks prior torandomization or plan to have a major surgery during conduct of the study (e.g.,aneurysm removal, stomach ligation).

• Participants with the following chronic or active infections: Are infected withhuman immunodeficiency virus (HIV), active hepatitis B virus (HBV) or hepatitis Cvirus(HCV) infection, active tuberculosis(TB)

• Active skin disease other than psoriasis (PsO) which could interfere with theassessment of PsO.

• History of fibromyalgia, any arthritis with onset prior to age 17 years, or currentdiagnosis of inflammatory joint disease other than psoriatic arthritis (PsA) (including but not limited to rheumatoid arthritis, gout, overlap connective tissuediseases, scleroderma, polymyositis, dermatomyositis, systemic lupus erythematosus).