Behavioral Activation for the PreVention of Post-strokE Depression in LoW-incomE Older Stroke Survivors

Last updated: April 22, 2026
Sponsor: The University of Texas Health Science Center, Houston
Overall Status: Active - Recruiting

Phase

N/A

Condition

Stroke

Depression

Cerebral Ischemia

Treatment

Tele-delivered Behavioral Activation by lay counselors after Stroke (Tele-BA-S)

Treatment as Usual

Clinical Study ID

NCT06864715
HSC-SN-25-0265
  • Ages > 55
  • All Genders

Study Summary

The overall objective of the project is to determine the effectiveness of tele-delivered behavioral activation (BA) by trained lay counselors (Tele-BA-S) to prevent Post-stroke depression (PSD) in low-income, older stroke survivors with subthreshold depression (SD).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Enrollment within 3-months +2 weeks of a first-time ischemic or hemorrhagic stroke

  • 24-item HDRS score < 15 indicating subthreshold depression defined as the absence ofdepressive symptoms or presence of mild symptoms of depression

  • Single person income less than or equal to $45,000

  • Residing in a community residence

  • Ability to speak and read in English or Spanish

  • Mini-MoCA score > or equal to 11

Exclusion

Exclusion Criteria:

  • Stroke event unrelated to vascular risk factors (e.g., drug use) or transientischemic attack

  • 24-item HDRS score > or equal to 15 indicating moderate to severe depression

  • Actively participating in psychotherapy

  • high suicide risk or severe psychiatric illness (e.g., bipolar disorder and activepsychosis) and/or actively taking antipsychotics

  • Diagnosed dementia and/or currently taking cognitive enhancers, amyloid-targetingmedications, or orexin receptor antagonists

  • Patient Health Questionnaire 9 score > or equal to 10 and/or answers positive to Q9

  • Diagnosed aphasia and/or severe cognitive impairments

  • high-risk alcohol or drug misuse

  • receiving medications for mood disorders and a change in dose or type within thelast 4 weeks

Study Design

Total Participants: 350
Treatment Group(s): 2
Primary Treatment: Tele-delivered Behavioral Activation by lay counselors after Stroke (Tele-BA-S)
Phase:
Study Start date:
April 10, 2026
Estimated Completion Date:
November 01, 2029

Connect with a study center

  • The University of Texas Health Science Center at Houston

    Houston, Texas 77030
    United States

    Active - Recruiting

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