A Study to Investigate Tonlamarsen for the Treatment of Adults With Uncontrolled Hypertension (KARDINAL)

Last updated: March 28, 2026
Sponsor: Kardigan, Inc.
Overall Status: Completed

Phase

2

Condition

Williams Syndrome

Stress

Vascular Diseases

Treatment

Placebo

Tonlamarsen

Clinical Study ID

NCT06864104
TLA-201
  • Ages 18-80
  • All Genders

Study Summary

The purpose of this study is to evaluate the blood pressure (BP)-lowering efficacy of tonlamarsen in adult participants who, despite taking 2 or more antihypertensive medications, have not achieved their target blood pressure (BP).

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

  • Age 18 to 80, body weight ≥ 50 kg

  • Has uncontrolled hypertension while receiving between 2 and 5 antihypertensivemedications prescribed for hypertension

  • Has mean office seated systolic blood pressure > 135 to ≤ 170 mmHg

Exclusion

Key Exclusion Criteria:

  • Has known history of secondary hypertension

  • Has documented history of poor adherence to antihypertensive medication

  • Has unstable/underlying known cardiovascular disease

  • Has abnormal thyroid function with clinical significance

Study Design

Total Participants: 206
Treatment Group(s): 2
Primary Treatment: Placebo
Phase: 2
Study Start date:
April 10, 2025
Estimated Completion Date:
March 17, 2026

Connect with a study center

  • Pinnacle Research Group

    Anniston, Alabama 36207
    United States

    Site Not Available

  • Achieve Clinical Research, LLC

    Birmingham, Alabama 35216
    United States

    Site Not Available

  • Elite Clinical Studies

    Phoenix, Arizona 85018
    United States

    Site Not Available

  • Del Sol Research Management, LLC

    Tucson, Arizona 85715
    United States

    Site Not Available

  • Cardiology and Medicine Clinic

    Little Rock, Arkansas 72204
    United States

    Site Not Available

  • North Coast Cardiology

    Encinitas, California 92024
    United States

    Site Not Available

  • Orange County Research Center

    Lake Forest, California 92630
    United States

    Site Not Available

  • Clinical Trials Research

    Lincoln, California 95648
    United States

    Site Not Available

  • American Institute of Research

    Los Angeles, California 90017
    United States

    Site Not Available

  • Homestead Associates in Research, Inc.

    Homestead, Florida 33033
    United States

    Site Not Available

  • Jacksonville Center for Clinical Research

    Jacksonville, Florida 32216
    United States

    Site Not Available

  • Suncoast Clinical Research, Inc.

    New Port Richey, Florida 34652
    United States

    Site Not Available

  • Progressive Medical Research

    Port Orange, Florida 32127
    United States

    Site Not Available

  • Agile Clinical Research Trials, LLC

    Atlanta, Georgia 30328
    United States

    Site Not Available

  • Velocity Clinical Reseach

    Savannah, Georgia 31406
    United States

    Site Not Available

  • Eagle Clinical Research

    Chicago, Illinois 60621
    United States

    Site Not Available

  • Clinical Investigation Specialists, Inc.

    Gurnee, Illinois 60031
    United States

    Site Not Available

  • Koch Family Medicine Clinical Research

    Morton, Illinois 61550
    United States

    Site Not Available

  • Tandem Clinical Research GI, LLC

    Marrero, Louisiana 70072
    United States

    Site Not Available

  • IMA Clinical Research

    Monroe, Louisiana 71201
    United States

    Site Not Available

  • DelRicht Clinical Research - New Orleans

    New Orleans, Louisiana 70115
    United States

    Site Not Available

  • ActivMed Practices & Research, LLC

    Methuen, Massachusetts 01844
    United States

    Site Not Available

  • Oakland Medical Research Center

    Troy, Michigan 48085
    United States

    Site Not Available

  • Olive Branch Family Medical Center

    Olive Branch, Mississippi 38654
    United States

    Site Not Available

  • Richmond University Medical Center

    Staten Island, New York 10310
    United States

    Site Not Available

  • CHEAR Center LLC

    The Bronx, New York 10455
    United States

    Site Not Available

  • IMA Clinical Research

    Lenoir, North Carolina 28645
    United States

    Site Not Available

  • Clinical Trials of South Carolina

    Moncks Corner, South Carolina 29461
    United States

    Site Not Available

  • Health Concepts

    Rapid City, South Dakota 57702
    United States

    Site Not Available

  • Holston Medical Group

    Kingsport, Tennessee 37660
    United States

    Site Not Available

  • Central Texas Clinical Research

    Austin, Texas 78705
    United States

    Site Not Available

  • Advanced Medical Trials Georgetown, LLC

    Georgetown, Texas 78628
    United States

    Active - Recruiting

  • Advanced Medical Trials, LLC

    Georgetown, Texas 78628
    United States

    Site Not Available

  • Juno Research, LLC

    Houston, Texas 77040
    United States

    Site Not Available

  • Radiance Clinical Research

    Lampasas, Texas 76550
    United States

    Site Not Available

  • Synergy Groups Medical

    Missouri City, Texas 77459
    United States

    Active - Recruiting

  • Synergy Groups Medical, LLC

    Missouri City, Texas 77459
    United States

    Site Not Available

  • North Hills Medical Research

    North Richland Hills, Texas 76180
    United States

    Site Not Available

  • North Hills Medical Research Inc.

    North Richland Hills, Texas 76180
    United States

    Active - Recruiting

  • Sun Research Institute

    San Antonio, Texas 78215
    United States

    Site Not Available

  • Manassas Clinical Research Center

    Manassas, Virginia 20110
    United States

    Site Not Available

  • York Clinical Research LLC

    Norfolk, Virginia 23504
    United States

    Site Not Available

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