A Study to Investigate Tonlamarsen for the Treatment of Adults With Uncontrolled Hypertension (KARDINAL)

Last updated: September 30, 2025
Sponsor: Kardigan, Inc.
Overall Status: Active - Not Recruiting

Phase

2

Condition

Stress

Circulation Disorders

Williams Syndrome

Treatment

Placebo

Tonlamarsen

Clinical Study ID

NCT06864104
TLA-201
  • Ages 18-80
  • All Genders

Study Summary

The purpose of this study is to evaluate the blood pressure-lowering effect of tonlamarsen in adult participants who, despite taking 2 or more antihypertensive medications, have not achieved their target blood pressure (BP).

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

  • Age 18 to 80, body weight ≥ 50 kg

  • Has uncontrolled hypertension while receiving between 2 and 5 antihypertensivemedications prescribed for hypertension

  • Has mean office seated systolic blood pressure > 135 to ≤ 170 mmHg

Exclusion

Key Exclusion Criteria:

  • Has known history of secondary hypertension

  • Has documented history of poor adherence to antihypertensive medication

  • Has unstable/underlying known cardiovascular disease

  • Has abnormal thyroid function with clinical significance

Study Design

Total Participants: 206
Treatment Group(s): 2
Primary Treatment: Placebo
Phase: 2
Study Start date:
April 10, 2025
Estimated Completion Date:
March 06, 2026

Connect with a study center

  • Pinnacle Research Group

    Anniston, Alabama 36207
    United States

    Site Not Available

  • Achieve Clinical Research, LLC

    Birmingham, Alabama 35216
    United States

    Site Not Available

  • Pinnacle Research Group

    Anniston 4830198, Alabama 4829764 36207
    United States

    Site Not Available

  • Achieve Clinical Research, LLC

    Birmingham 4049979, Alabama 4829764 35216
    United States

    Site Not Available

  • Elite Clinical Studies

    Phoenix, Arizona 85018
    United States

    Site Not Available

  • Del Sol Research Management, LLC

    Tucson, Arizona 85715
    United States

    Site Not Available

  • Elite Clinical Studies

    Phoenix 5308655, Arizona 5551752 85018
    United States

    Site Not Available

  • Del Sol Research Management, LLC

    Tucson 5318313, Arizona 5551752 85715
    United States

    Site Not Available

  • Cardiology and Medicine Clinic

    Little Rock, Arkansas 72204
    United States

    Site Not Available

  • Cardiology and Medicine Clinic

    Little Rock 4119403, Arkansas 4099753 72204
    United States

    Site Not Available

  • North Coast Cardiology

    Encinitas, California 92024
    United States

    Site Not Available

  • Orange County Research Center

    Lake Forest, California 92630
    United States

    Site Not Available

  • Clinical Trials Research

    Lincoln, California 95648
    United States

    Site Not Available

  • American Institute of Research

    Los Angeles, California 90017
    United States

    Site Not Available

  • North Coast Cardiology

    Encinitas 5346646, California 5332921 92024
    United States

    Site Not Available

  • Orange County Research Center

    Lake Forest 5364514, California 5332921 92630
    United States

    Site Not Available

  • Clinical Trials Research

    Lincoln 5366375, California 5332921 95648
    United States

    Site Not Available

  • American Institute of Research

    Los Angeles 5368361, California 5332921 90017
    United States

    Site Not Available

  • Homestead Associates in Research, Inc.

    Homestead, Florida 33033
    United States

    Site Not Available

  • Jacksonville Center for Clinical Research

    Jacksonville, Florida 32216
    United States

    Site Not Available

  • Suncoast Clinical Research, Inc.

    New Port Richey, Florida 34652
    United States

    Site Not Available

  • Progressive Medical Research

    Port Orange, Florida 32127
    United States

    Site Not Available

  • Homestead Associates in Research, Inc.

    Homestead 4159050, Florida 4155751 33033
    United States

    Site Not Available

  • Jacksonville Center for Clinical Research

    Jacksonville 4160021, Florida 4155751 32216
    United States

    Site Not Available

  • Suncoast Clinical Research, Inc.

    New Port Richey 4165869, Florida 4155751 34652
    United States

    Site Not Available

  • Progressive Medical Research

    Port Orange 4169156, Florida 4155751 32127
    United States

    Site Not Available

  • Agile Clinical Research Trials, LLC

    Atlanta, Georgia 30328
    United States

    Site Not Available

  • Velocity Clinical Reseach

    Savannah, Georgia 31406
    United States

    Site Not Available

  • Agile Clinical Research Trials, LLC

    Atlanta 4180439, Georgia 4197000 30328
    United States

    Site Not Available

  • Velocity Clinical Reseach

    Savannah 4221552, Georgia 4197000 31406
    United States

    Site Not Available

  • Eagle Clinical Research

    Chicago, Illinois 60621
    United States

    Site Not Available

  • Clinical Investigation Specialists, Inc.

    Gurnee, Illinois 60031
    United States

    Site Not Available

  • Koch Family Medicine Clinical Research

    Morton, Illinois 61550
    United States

    Site Not Available

  • Eagle Clinical Research

    Chicago 4887398, Illinois 4896861 60621
    United States

    Site Not Available

  • Clinical Investigation Specialists, Inc.

    Gurnee 4894861, Illinois 4896861 60031
    United States

    Site Not Available

  • Koch Family Medicine Clinical Research

    Morton 4902754, Illinois 4896861 61550
    United States

    Site Not Available

  • Tandem Clinical Research GI, LLC

    Marrero, Louisiana 70072
    United States

    Site Not Available

  • IMA Clinical Research

    Monroe, Louisiana 71201
    United States

    Site Not Available

  • DelRicht Clinical Research - New Orleans

    New Orleans, Louisiana 70115
    United States

    Site Not Available

  • Tandem Clinical Research GI, LLC

    Marrero 4332628, Louisiana 4331987 70072
    United States

    Site Not Available

  • IMA Clinical Research

    Monroe 4333669, Louisiana 4331987 71201
    United States

    Site Not Available

  • DelRicht Clinical Research - New Orleans

    New Orleans 4335045, Louisiana 4331987 70115
    United States

    Site Not Available

  • ActivMed Practices & Research, LLC

    Methuen, Massachusetts 01844
    United States

    Site Not Available

  • ActivMed Practices & Research, LLC

    Methuen 4943828, Massachusetts 6254926 01844
    United States

    Site Not Available

  • Oakland Medical Research Center

    Troy, Michigan 48085
    United States

    Site Not Available

  • Oakland Medical Research Center

    Troy 5012639, Michigan 5001836 48085
    United States

    Site Not Available

  • Olive Branch Family Medical Center

    Olive Branch, Mississippi 38654
    United States

    Site Not Available

  • Olive Branch Family Medical Center

    Olive Branch 4439869, Mississippi 4436296 38654
    United States

    Site Not Available

  • Chear Center LLC

    Bronx, New York 10455
    United States

    Site Not Available

  • Richmond University Medical Center

    Staten Island 5139568, New York 5128638 10310
    United States

    Site Not Available

  • CHEAR Center LLC

    The Bronx 5110266, New York 5128638 10455
    United States

    Site Not Available

  • IMA Clinical Research

    Lenoir, North Carolina 28645
    United States

    Site Not Available

  • IMA Clinical Research

    Lenoir 4475640, North Carolina 4482348 28645
    United States

    Site Not Available

  • Clinical Trials of South Carolina

    Moncks Corner, South Carolina 29461
    United States

    Site Not Available

  • Clinical Trials of South Carolina

    Moncks Corner 4587511, South Carolina 4597040 29461
    United States

    Site Not Available

  • Health Concepts

    Rapid City, South Dakota 57702
    United States

    Site Not Available

  • Health Concepts

    Rapid City 5768233, South Dakota 5769223 57702
    United States

    Site Not Available

  • Holston Medical Group

    Kingsport, Tennessee 37660
    United States

    Site Not Available

  • Holston Medical Group

    Kingsport 4634662, Tennessee 4662168 37660
    United States

    Site Not Available

  • Central Texas Clinical Research

    Austin, Texas 78705
    United States

    Site Not Available

  • Advanced Medical Trials Georgetown, LLC

    Georgetown, Texas 78628
    United States

    Active - Recruiting

  • Advanced Medical Trials, LLC

    Georgetown, Texas 78628
    United States

    Site Not Available

  • Juno Research, LLC

    Houston, Texas 77040
    United States

    Site Not Available

  • Radiance Clinical Research

    Lampasas, Texas 76550
    United States

    Site Not Available

  • Synergy Groups Medical

    Missouri City, Texas 77459
    United States

    Active - Recruiting

  • Synergy Groups Medical, LLC

    Missouri City, Texas 77459
    United States

    Site Not Available

  • North Hills Medical Research

    North Richland Hills, Texas 76180
    United States

    Site Not Available

  • North Hills Medical Research Inc.

    North Richland Hills, Texas 76180
    United States

    Active - Recruiting

  • Sun Research Institute

    San Antonio, Texas 78215
    United States

    Site Not Available

  • Central Texas Clinical Research

    Austin 4671654, Texas 4736286 78705
    United States

    Site Not Available

  • Advanced Medical Trials, LLC

    Georgetown 4693342, Texas 4736286 78628
    United States

    Site Not Available

  • Juno Research, LLC

    Houston 4699066, Texas 4736286 77040
    United States

    Site Not Available

  • Radiance Clinical Research

    Lampasas 4705176, Texas 4736286 76550
    United States

    Site Not Available

  • Synergy Groups Medical, LLC

    Missouri City 4711801, Texas 4736286 77459
    United States

    Site Not Available

  • North Hills Medical Research

    North Richland Hills 4715292, Texas 4736286 76180
    United States

    Site Not Available

  • Sun Research Institute

    San Antonio 4726206, Texas 4736286 78215
    United States

    Site Not Available

  • Manassas Clinical Research Center

    Manassas, Virginia 20110
    United States

    Site Not Available

  • York Clinical Research LLC

    Norfolk, Virginia 23504
    United States

    Site Not Available

  • Manassas Clinical Research Center

    Manassas 4771401, Virginia 6254928 20110
    United States

    Site Not Available

  • York Clinical Research LLC

    Norfolk 4776222, Virginia 6254928 23504
    United States

    Site Not Available

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