A Prospective Study Evaluating the Impact of Conservative Management on Retained Products of Conception and EMV

Last updated: March 2, 2025
Sponsor: Fu Xing Hospital, Capital Medical University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Miscarriage

Treatment

N/A

Clinical Study ID

NCT06862089
2024FXHEC-KSP073
  • Female

Study Summary

The goal of this observational study is to learn about the therapeutic effects of the conservative treatment approach on pepole with retained products of conception (RPOC) and Enhanced myometrial vascularity (EMV).

The main question it aims to answer is: Is it possible to achieve the natural resolution of RPOC by combining it with EMV through conservative treatment？ Participants will receive conservative treatment (such as mifepristone, GnRH-a, or expectant management) following the initial diagnosis of RPOC and EMV, and the therapeutic efficacy of the conservative approach will be assessed after the completion of two menstrual cycles.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Recent history of miscarriage or delivery (within the past 8 weeks)

  • Strong willingness to undergo conservative management

  • Hemodynamically stable

  • Signed informed consent form

Exclusion

Exclusion Criteria:

  • Heavy vaginal bleeding (requiring immediate surgical intervention)

  • Active pelvic or systemic infection (e.g., fever >38°C, elevated CRP/WBC)

  • Severe dysfunction of vital organs (heart, liver, or kidney)

  • Known drug allergies or contraindications to proposed medications (e.g., misoprostolintolerance)

  • Suspected ectopic pregnancy or gestational trophoblastic disease (confirmed byultrasound or β-hCG levels)

  • Placenta accreta spectrum disorders diagnosed during current pregnancy

  • History of uterine artery embolization

Study Design

Total Participants: 120
Study Start date:
November 09, 2024
Estimated Completion Date:
June 30, 2027

Connect with a study center

  • Hysteroscopy Center, Fuxing Hospital, Capital Medical University

    Beijing, 100086
    China

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.