Safety of Short-course of NSAIDs in Pediatric Patients With CKD

Last updated: June 4, 2026
Sponsor: University of Colorado, Denver
Overall Status: Active - Recruiting

Phase

4

Condition

Nephropathy

Focal Segmental Glomerulosclerosis

Kidney Disease

Treatment

Placebo

NSAIDs

Clinical Study ID

NCT06860711
24-1252
  • Ages 18-25
  • All Genders

Study Summary

The purpose of this study is to determine if non-steroidal anti-inflammatory (NSAID) use in the postoperative setting increases the risk of acute kidney injury (AKI) in pediatric patients with mild-to-moderate chronic kidney disease (CKD). The investigators hypothesize that there is no increased risk. This is currently in the process of developing multi institution collaboration within a Pediatric Urology population, intended to inform future work in a larger patient population.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients over 18 months of age

  • diagnosis of CKD stages 2-3a, confirmed by CKiD U25 eGFR calculator based oncystatin C laboratory testing within 6 months of surgery

  • Patient is scheduled to undergo a urologic surgery requiring admission or overnightstay in the hospital

Exclusion

Exclusion Criteria:

  • Diagnosis of CKD stage 1 or 4-5

  • Past medical history of renal transplant

  • Past medical history of nasal polyp

  • Procedure for oncologic indications or on chemotherapy

  • Pregnant patient

  • True allergy to NSAIDs

Study Design

Total Participants: 164
Treatment Group(s): 2
Primary Treatment: Placebo
Phase: 4
Study Start date:
July 22, 2025
Estimated Completion Date:
December 31, 2028

Connect with a study center

  • Children's Hospital Colorado

    Aurora, Colorado 80045
    United States

    Active - Recruiting

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