Randomized Clinical Trial of TUNE In 3.0: A Social/Emotional Program for Adults With Autism Spectrum Disorder

Last updated: April 22, 2025
Sponsor: University of Pennsylvania
Overall Status: Active - Recruiting

Phase

N/A

Condition

Autism

Williams Syndrome

Asperger's Disorder

Treatment

TUNE In: Training to Understand and Navigate Emotions and Interactions

Clinical Study ID

NCT06859918
TUNE In 3.0
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to test a novel, cognitive behavioral treatment strategy to improve social functioning in adults with autism spectrum disorder.

The treatment, named TUNE In (Training to Understand and Navigate Emotions and Interactions), includes components to address the many behavioral domains involved in social functioning, including social motivation, social anxiety, social cognition, social skills, and generalization of the skills to community settings.

The Investigators will test the efficacy of TUNE In to improve social functioning in adults with autism spectrum disorder (ASD), using a randomized controlled trial using the SRS-2 as the primary outcome measure.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • 18 years of age or older

  • Meet ASD diagnostic criteria supported by an outside diagnostic evaluation and/or bythe clinical and developmental information gathered from a phone screen

  • Be willing to complete screening surveys (outcome measures)

  • Social Responsiveness Score, Second Edition, self-report SRS survey score of greaterthan or equal to 60

Exclusion

Exclusion Criteria:

  • Severe self-injurious or aggressive behaviors; or with suicidal or homicidalideation or behaviors (e.g. suicide attempt) within the last 6 months

  • Major mood episode (major depressive episode, manic episode), psychotic symptoms, ora psychiatric hospitalization within the last 6 months

  • A history of intellectual disability or low Shipley-2 score

Study Design

Total Participants: 40
Treatment Group(s): 1
Primary Treatment: TUNE In: Training to Understand and Navigate Emotions and Interactions
Phase:
Study Start date:
March 24, 2025
Estimated Completion Date:
December 31, 2027

Connect with a study center

  • Brodkin Lab: Perelman School of Medicine, Department of Psychiatry, University of Pennsylvania

    Philadelphia, Pennsylvania 19104
    United States

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.