A Multi-Center Observational Trial of Symptomatic, High-Risk Bone Metastases Treated With Percutaneous Ablation and Palliative Radiation Therapy

Inclusion Criteria:

• 1. Skeletal metastasis with localized pain not controlled medically [recall withinlast 24 hours of worst pain ≥ 5 using the BPI]
• 2. Pain must be from one painful metastatic lesion involving the bone (additionalless painful metastatic sites may be present). Extra-osseous extension of disease isallowed (must have some contact with the bone and be causing bone/tumor interfacepain)
• 3. Lesions that are at high-risk of skeletal related events defined as follows:

• a. Minimum Spinal Instability Neoplastic Score (SINS) score ≥ 7 for lesionsinvolving the spine

• b. Pelvic and appendicular lytic lesions with or without cortical breakthroughcausing functional/mechanical pain

• 4. Target lesion amenable to percutaneous ablation with image guidance AND RT byspecialists' review
• 5. No prior targeted radiation therapy or ablation to the index lesion
• 6. ECOG performance status 0-2
• 7. Age ≥ 21 years
• 8. Have signed the current approved informed consent form
• 9. Willing and able to answer follow-up Patient Reported Outcomes (PRO) surveys (e.g., PROMIS®, BPI, COST-FACIT, and OMED) for up to 12 months
• 10. Life expectancy > 3 months

Exclusion Criteria:

• 1. Any medical or personal condition that, in the opinion of the site investigator,may potentially compromise the safety or compliance of the patient, or may precludethe patient's successful completion of the clinical trial.
• 2. Target tumor involves a weight-bearing long bone of the lower extremity with thetumor causing > 50% loss of cortical bone [MIREL Score ≥ 7]
• 3. Skeletal lesions with unstable pathologic fractures requiring immediate surgicalstabilization
• 4. Concurrent participation in other studies that could affect the primary endpoint
• 5. Target tumor causing clinical or imaging evidence of spinal cord compression