A Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With Obesity

Inclusion Criteria:

• Have obesity and a history of at least one self-reported unsuccessful dietary effortto reduce body weight

Exclusion Criteria:

• Have a self-reported change in body weight >5 kilograms (kg) (11 pounds) within 90days before screening

• Have a prior or planned surgical treatment for obesity

• Have a prior or planned endoscopic procedure and/or device-based therapy for obesity

• Have Type 1 Diabetes, Type 2 Diabetes, or any other type of diabetes

• Have a family or personal history of medullary thyroid carcinoma (MTC) or multipleendocrine neoplasia syndrome type 2 (MEN-2)

• Have had within the past 90 days before screening:

• acute myocardial infarction

• cerebrovascular accident (stroke)

• hospitalization for unstable angina, or

• hospitalization due to congestive heart failure

• Have New York Heart Association Functional Classification Class IV congestive heartfailure

• Have a history of chronic or acute pancreatitis

• Have taken weight loss drugs, including over-the-counter medications, within 90 daysprior to screening