Efficacy and Safety of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight

Inclusion Criteria:

• Age ≥ 18 years.

• Body mass index ≥ 27 kg/m^2.

• History of at least 1 self-reported unsuccessful attempt at weight loss by diet andexercise.

• Diagnosis of T2DM.

Exclusion Criteria:

• Type 1 diabetes mellitus.

• Self-reported change in body weight > 5 kg within 90 days before screening.

• Proliferative diabetic retinopathy OR diabetic macular edema OR non-proliferativediabetic retinopathy that requires acute treatment.

• Obesity induced by other endocrinologic disorders.

• Family (first-degree relative[s]) or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2.

• History of chronic pancreatitis or history of acute pancreatitis within 180 daysbefore screening.

• History of unstable major depressive disorder (MDD) or other severe psychiatricdisorder within 2 years before screening.

• Lifetime history of suicide attempt.