Evaluation of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight

Inclusion Criteria:

• Age ≥ 18 years.

• Body mass index ≥ 30 kg/m2 or ≥27 kg/m² to < 30 kg/m2 with at least 1 of thefollowing weight-related comorbidities: hypertension, dyslipidemia, history ofobstructive sleep apnea, history of cardiovascular disease, history of metabolicdysfunction-associated steatotic liver disease (MASLD) or MetabolicDysfunction-Associated Steatohepatitis (MASH).

• History of at least 1 self-reported unsuccessful attempt at weight loss by diet andexercise.

Exclusion Criteria:

• Type 1 or Typ2 diabetes mellitus.

• Obesity induced by other endocrinologic disorders.

• Self-reported change in body weight > 5 kg within 90 days before screening.

• Family (first-degree relative[s]) or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2.

• History of chronic pancreatitis or history of acute pancreatitis within 180 daysbefore screening.

• History of unstable major depressive disorder (MDD) or other severe psychiatricdisorder within 2 years before screening.

• Lifetime history of suicide attempt.