Budesonide Nasal Irrigation Versus Fluticasone Propionate Nasal Spray in Treating Allergic Rhinitis Patients

Last updated: February 27, 2025
Sponsor: Benha University
Overall Status: Completed

Phase

4

Condition

Allergy

Acute Rhinitis

Common Cold

Treatment

Budesonide buffered with 0.9% isotonic saline.

0.9% saline for nasal irrigation.

Fluticasone propionate nasal spray.

Clinical Study ID

NCT06858423
MS-8-8-2023
  • Ages 18-60
  • All Genders

Study Summary

Budesonide is a medication of the corticosteroid type. Available as an inhaler, nebulization solution, The inhaled form is used in the long-term management of asthma and chronic obstructive pulmonary disease is used for allergic rhinitis and nasal polyps fluticasone propionate

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adult age between 18 and 60 years old.

  • Patients with allergic rhinitis evidence by past skin prick testing. Patients weregiven a skin prick test with a panel of dog, cat, Dermatophagoides farinae, Dpteronyssinus, Alternaria, Penicillium, Hormodendron, Aspergillus, grass pollen mix,tree pollen mix, and ragweed allergen extracts (100,000 Allergen Unit/mL).Histamine, 10 mg/mL, was used as a positive control, and the diluent was used as thenegative control. A positive reaction was defined as a wheal diameter at least 3 mmgreater than the diluent control and/or at least a 50-mm flare (ie, erythemameasured as the sum of the greatest diameter and the perpendicular diameter throughthe midpoint of the greatest diameter)

Exclusion

Exclusion Criteria:

  • Patients who had autoimmune diseases or any immune compromised diseases includingdiabetes, chemotherapy.

  • Patients with a history of nasal surgery.

  • Patients who received systemic or topical corticosteroids, herbal drugs, betablocking agent within the previous month of enrolment.

  • Patients with asthma and COPD, nasal bleeding, obstructing nasal polyps, paranasalsinus.

Study Design

Total Participants: 360
Treatment Group(s): 3
Primary Treatment: Budesonide buffered with 0.9% isotonic saline.
Phase: 4
Study Start date:
August 15, 2023
Estimated Completion Date:
May 31, 2024

Study Description

The current study aims to compare between results of budesonid nasal irrigation and fluticasone nasal spray in the treatment of adult patients with Allergic Rhinitis.

Connect with a study center

  • Benha University Hospitals - Otolaryngology department

    Banhā, Qalyobia 6460001
    Egypt

    Site Not Available

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