Phase
Condition
Williams Syndrome
Vascular Diseases
Stress
Treatment
Saline
QCZ484
Clinical Study ID
Ages 18-75 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Signed informed consent.
Males or females aged 18 to 75 years.
Diagnosis of hypertension.
Hypertension treatment naive or on maximum 2 anti-HTN medications and able toundergo washout for 4 weeks.
Mean sitting SBP ≥140 mmHg measured by OBPM and mean 24 hr SBP ≥130 mmHg and <160mmHg measured by ABPM.
Participants able to understand and comply with study procedures.
Exclusion
Exclusion Criteria:
Known history of secondary hypertension.
Orthostatic hypotension.
Laboratory parameter assessments outside of range at screening.
Evidence of hepatic disease.
Medical condition, other than hypertension, requiring treatment with RAAS inhibitor.
Any history of congestive heart failure.
Current or history of intolerance to ACEi and/or ARBs.
Clinically significant cardiac arrhythmias, high-grade AV block and third-degree AVblock within 6 months prior to screening.
Acute myocardial infarction (AMI) or unstable angina, or any percutaneous coronaryintervention (PCI) or coronary artery bypass graft (CABG) within 12 months prior toscreening. Any history of ischemic or hemorrhagic stroke or transient ischemicattack any time prior to screening.
Other protocol-defined inclusion/exclusion criteria may apply
Study Design
Study Description
Connect with a study center
Novartis Investigative Site
Suita, Osaka 565-0853
JapanActive - Recruiting
Novartis Investigative Site
Chuo Ku, Tokyo 103-0027
JapanActive - Recruiting
Novartis Investigative Site
Chuo ku, Tokyo 104-0031
JapanActive - Recruiting
Novartis Investigative Site
Chuo-ku, Tokyo 103-0027
JapanActive - Recruiting
Novartis Investigative Site
Shinjuku ku, Tokyo 160-0008
JapanActive - Recruiting
Novartis Investigative Site
Singapore, 308433
SingaporeActive - Recruiting
SEC Clinical Research LLC
Andalusia, Alabama 36420
United StatesActive - Recruiting
Synexus Clinical Research US Inc
Tucson, Arizona 85741
United StatesActive - Recruiting
NICRs Research Center
Garden Grove, California 92844
United StatesActive - Recruiting
Downtown L.A. Research Center Inc
Los Angeles, California 90017
United StatesActive - Recruiting
Clinical Trials Research Sacramento
Sacramento, California 95821-2134
United StatesActive - Recruiting
Encompass Clinical Research
Spring Valley, California 91978-1522
United StatesActive - Recruiting
Clinical Research of Brandon LLC
Brandon, Florida 33511
United StatesActive - Recruiting
ALL Medical Research LLC
Cooper City, Florida 33024
United StatesActive - Recruiting
Cen Exel RCA
Hollywood, Florida 33024
United StatesActive - Recruiting
East Coast Institute for Research
Jacksonville, Florida 32223
United StatesActive - Recruiting
Entrust Clinical Research
Miami, Florida 33176
United StatesActive - Recruiting
Inpatient Research Clinical LLC
Miami Lakes, Florida 33014
United StatesActive - Recruiting
Suncoast Clinical Research
New Port Richey, Florida 34452
United StatesActive - Recruiting
American Research Centers of FL
Pembroke Pines, Florida 33027
United StatesActive - Recruiting
Cen Exel FCR
Tampa, Florida 33613
United StatesActive - Recruiting
Cardiology Partners Clinical Research Institute
Wellington, Florida 33449
United StatesActive - Recruiting
Centricity Research
Columbus, Georgia 31904
United StatesActive - Recruiting
Javara Research
Fayetteville, Georgia 30214
United StatesActive - Recruiting
Solaris Clinical Research
Meridian, Idaho 83646
United StatesActive - Recruiting
Cedar Crosse Research Ct
Chicago, Illinois 60607
United StatesActive - Recruiting
Eagle Clinical Research
Chicago, Illinois 60621
United StatesActive - Recruiting
Synexus Clinical Research US
Evansville, Indiana 47714
United StatesActive - Recruiting
Alliance for Multispecialty Resrch
Wichita, Kansas 67207
United StatesActive - Recruiting
Ascension Saint Agnes Heart Care
Baltimore, Maryland 21229
United StatesActive - Recruiting
Anderson Medical Research
Fort Washington, Maryland 20744
United StatesActive - Recruiting
Capitol Cardiology Associates
Lanham, Maryland 20706
United StatesActive - Recruiting
Oakland Medical Research Center
Troy, Michigan 48085
United StatesActive - Recruiting
Synexus Clinical Research US Inc
Richfield, Minnesota 55432
United StatesActive - Recruiting
Healthcare Research Network II LLC
Hazelwood, Missouri 63042
United StatesActive - Recruiting
Jefferson City Medical Group
Jefferson City, Missouri 65109
United StatesActive - Recruiting
CenExel HRI
Berlin, New Jersey 08009
United StatesActive - Recruiting
Monroe Biomedical Research
Monroe, North Carolina 28112
United StatesActive - Recruiting
Burke Primary Care
Morganton, North Carolina 28655
United StatesActive - Recruiting
Conrad Clinical Research
Edmond, Oklahoma 73013
United StatesActive - Recruiting
Clinical Neuroscience Solutions Inc
Memphis, Tennessee 38119
United StatesActive - Recruiting
North Hills Medical Research Inc
Bedford, Texas 76021
United StatesActive - Recruiting
Synergy Groups Medical LLC
Missouri City, Texas 77459
United StatesActive - Recruiting
Sun Research Institute
San Antonio, Texas 78205
United StatesActive - Recruiting
Manassas Clinical Research Center
Manassas, Virginia 20110
United StatesActive - Recruiting
Dominion Medical Associates
Richmond, Virginia 23219
United StatesActive - Recruiting
Centricity Research Suffolk Fam Med
Suffolk, Virginia 23434
United StatesActive - Recruiting
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