Performance and Safety of LightForce® Therapy Lasers on Lateral Ankle Sprain

Inclusion Criteria:

1. Patient male or female with age ≥18 years old

2. Patient with diagnosis of LAS (as confirmed by physical examination) to be treatedby LightForce® Therapy Lasers according to its indications.

3. Patient suffering from LAS pain for no more than 72 hours prior to enrollment

4. Pain (either persistent or during activities) score reported by the subject atbaseline ≥ 40 mm measured on VAS

5. Patient able to provide written informed consent

Exclusion Criteria:

1. Patient with musculoskeletal pathological conditions not to be treatedwith/contraindication to the use of LightForce® Therapy Lasers according to itsintended use and indications

2. Patients who are taking drugs that have heat or light sensitive contraindications,such as but not limited to certain types of steroids

3. Patients who have been administered with corticosteroids after injury

4. Pregnant females or females of childbearing potentially planning to become pregnantduring the study participation

5. Patients who had systemic inflammatory conditions (i.e. rheumatoid arthritis,polymyalgia rheumatica)

6. Patients affected by chronic ankle instability (recurrent sprains, ankleinstability, functional ankle instability, mechanical ankle instability fol¬lowingthe first-time injury)

7. Patients with bilateral ankle sprain

8. Patients who have a disease that would limit their participation in exercises (i.e.severe chronic obstructive pulmonary disease, severe heart failure, cerebrovascularevent history)

9. Patients with fractures (as confirmed by radiological examination)

10. Patients with a diagnosis of active cancer

11. Patients with tattoos covering more than 30% of the area to be treated withLightForce® Therapy Lasers

12. Patients who are mentally or physically incapacitated

13. Patient participating in other clinical study or has completed a clinical study lessthan 30 days prior to enrollment

14. Patients with other clinically significant co-morbidities that make the patientunsuitable for study participation, at the discretion of the investigator