Phase
Condition
Acute Pain
Pain
Treatment
Ketamine
Esketamine
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Adult patients aged 18 or over,
consulting our emergency department for a medical or traumatic pathology responsiblefor acute (less than 7 days old) and severe pain (greater than or equal to 6 on theVerbal Numerical Rating Scale, which has 11 levels from 0 = no pain to 10 = maximumimaginable pain).
Free and informed consent given before the start of the trial.
Patients affiliated to social security system.
Exclusion
Exclusion Criteria:
Inability to quantify pain score ;
proven or suspected intoxication (drug or alcohol) leading to consciousnessdisorders (Glasgow score less than or equal to 15) ;
person under legal protection or deprived of liberty ;
pregnant or breast-feeding patients ;
known allergy to ketamine or esketamine ;
history of drug addiction or dependence ;
insufficiently controlled hyperthyroidism ;
history of cerebral of myocardial infarction ;
known severe heart failure ;
existence of intracranial hypertension, glaucoma or ocular trauma ;
unstable vital signs (systolic blood pressure < 90 mmHg or > 180, heart rate < 50per minute or > 150, respiratory rate < 10 per minute or > 30) ;
chronic treatment with aminophylline, theophylline or methylergometrine ;
administration of morphine or another opioid within one hour of inclusion ;
ongoing simultaneous participation in another study that could interfere with thetreatment studied or the results of statistical analysis.
Study Design
Study Description
Connect with a study center
CHU de NICE
Nice, Alpes-maritimes 06000
FranceActive - Recruiting
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