Double Dose 4-AP on Functional Recovery After Spinal Cord Injury

Inclusion Criteria:

• Male and females between ages 18-85 years

• SCI 6 months post injury

• Spinal Cord injury at or above L2

• ASIA A, B, C, or D, complete or incomplete

• The ability to perform a small visible contraction with dorsiflexion and hip flexormuscles

Exclusion Criteria:

• Uncontrolled medical problems including pulmonary, cardiovascular or orthopedicdisease

• Any history of renal impairment

• Any debilitating disease prior to the SCI that caused exercise intolerance

• Premorbid, ongoing major depression or psychosis, altered cognitive status

• History of head injury or stroke

• Vascular, traumatic, tumoral, infectious, or metabolic lesion of the brain, evenwithout history of seizure, and without anticonvulsant medication

• History of seizures or epilepsy

• Receiving drugs acting primarily on the central nervous system, which lower theseizure threshold (see appendix 2)

• Pregnant females

• If a women of child bearing age is unsure of the pregnancy, and does not want totake the pregnancy test

• Ongoing cord compression or a syrinx in the spinal cord or who suffer from a spinalcord disease such as spinal stenosis, spina bifida, MS, or herniated disk

• Metal plate in skull

• Individuals with scalp shrapnel, cochlear implants, or aneurysm clips

• Individuals taking Bupropion, Dolutegravir, Lacosamide, Trilaciclib, or PR Intervalprolonging drugs