Assessing the Immediate Increase in Serum Ferritin After Oral Iron Doses: an Experimental Study in Iron-deficient Women

Last updated: May 19, 2025
Sponsor: Swiss Federal Institute of Technology
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

ferrous sulfate 160 mg

ferrous sulfate 80 mg

Clinical Study ID

NCT06851130
INFER Study 2
  • Ages 18-45
  • Female

Study Summary

Serum ferritin is a key indicator of body iron stores and is widely used in monitoring iron status. However, oral iron doses can acutely elevate SF levels, potentially biasing assessments of iron stores during supplementation. This study aims to investigate the extent and duration of the acute iron-induced effect on serum ferritin following the administration of a daily iron dose for two months.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Low iron stores (SF levels < 30 µg/L),

  • no anemia (Hb > 120 g/L)

  • no inflammation (CRP < 5 mg/L)

  • 18 to 45 years old.

  • Body weight <70 kg

  • Normal body Mass Index (18.5-26.5 kg/m2)

Exclusion

Exclusion Criteria:

  • Any chronic or acute disease

  • Consumption of mineral and vitamin supplements since screening and over the studyperiod

  • Blood transfusion, blood donation or significant blood loss over the past 4 months,

  • Pregnant or breastfeeding,

  • Continuous/long-term use of medication during the whole studies (except forcontraceptives)

  • Therapeutic iron infusion over the past 6 months,

  • Known hypersensitivity or allergy to iron supplements,

  • Intention to become pregnant over the course of the study

Study Design

Total Participants: 120
Treatment Group(s): 2
Primary Treatment: ferrous sulfate 160 mg
Phase:
Study Start date:
February 25, 2025
Estimated Completion Date:
December 31, 2025

Connect with a study center

  • Laboratory of Nutrition and Metabolic Epigenetics

    Zurich, 8092
    Switzerland

    Active - Recruiting

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