Oral Metformin for Treating Melasma in Latin American Women

Last updated: February 19, 2025
Sponsor: University of Puerto Rico
Overall Status: Active - Recruiting

Phase

1/2

Condition

N/A

Treatment

Metformin

Clinical Study ID

NCT06845540
2406248489
  • Ages > 21
  • Female

Study Summary

The goal of this clinical trial is to learn if metformin can treat melasma in Latin American women. The main question it aims to answer is:

  • Can metformin help reduce the dark patches of melasma?

Researchers will test two different doses of metformin (500 mg and 1000 mg) to see if either one helps improve melasma.

Participants will:

  • Take a metformin pill every day for three months.

  • Go to the clinic twice: once at the beginning and once at the end of the study.

  • Get a phone call from the researchers to check how they're doing and ask about any changes or side effects.

Eligibility Criteria

Inclusion

Inclusion Criteria: Latin American women aged 21 years or older, diagnosed epidermal or mixed melasma

Exclusion

Exclusion Criteria: pregnancy, breastfeeding, use of hydroquinone or tretinoin within 2 months before the study, or undergoing laser treatment, peels, microdermabrasion, or microneedling within 2 months of the study. Patients with a history of renal or liver disease, metformin allergy, diabetes, hypoglycemia, or those on medications that could interact with metformin will also be excluded.

Study Design

Total Participants: 30
Treatment Group(s): 1
Primary Treatment: Metformin
Phase: 1/2
Study Start date:
February 20, 2025
Estimated Completion Date:
May 30, 2025

Connect with a study center

  • Administración de Servicios Médicos (ASEM) Clinicas Externas

    San Juan, 00935
    Puerto Rico

    Active - Recruiting

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