A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM

Inclusion Criteria:

Part A:

• Has a body mass index (BMI) of ≥27 kg/m^2 and <40 kg/m^2

Part B:

• Is an adult patient with a confirmed diagnosis of T2DM

• Has a hemoglobin A1c (HbA1c) ≥7% to <10.5%

• Has a BMI of ≥25 kg/m^2 and <45 kg/m^2

• Is on a stable dose of either metformin or metformin and a sodium-glucosecotransporter 2 inhibitor (SGLT2i)

Exclusion Criteria:

Part A:

• Has known human immunodeficiency virus (HIV) infection; or known current or chronichepatitis C virus or hepatitis B virus infection

Part B:

• Receiving therapies for chronic weight management or antidiabetic medications otherthan metformin and SGLT2i

Note: other protocol defined inclusion/exclusion criteria apply