A Phase II Clinical Study of SHR-1826 for Injection in Patients With NSCLC

Inclusion Criteria:

1. Subjects must voluntarily agree to participate in the trial and sign a writteninformed consent form.

2. ECOG performance score of 0-1.

3. Life expectancy ≥ 3 months.

4. Have at least one measurable tumor lesion per RECIST v1.1.

5. Subjects with histologically confirmed locally advanced or metastatic NSCLC.

6. Good level of organ function.

7. Provide archived or fresh tumor tissue for vendor test.

Exclusion Criteria:

1. Subjects with active central nervous system metastases or meningeal metastases;

2. History of serious cardiovascular and cerebrovascular diseases;

3. Subjects with a history of interstitial pneumonitis or imaging at screeningsuggestive of suspected interstitial pneumonitis;

4. Severe infection within 4 weeks prior to the first dose;

5. Ongoing or previous anti-tumor therapies within 4 weeks prior to the first dose ofstudy drug;

6. Subjects with uncontrolled tumor-related pain;

7. Received >30 Gy of non-thoracic radical radiation therapy within 4 weeks prior tothe first administration of study drug;

8. Concomitant other malignancies ≤ 5 years prior to first dose of study drug;

9. Unresolved toxicities from previous anti-tumor therapy to ≤ Grade 1 (based on NCICTCAE v5.0);

10. History of immunodeficiency, including a positive HIV test;

11. Per the investigator's judgment, there are any other circumstances that may increasethe risk of participating in the study, interfere with the study results, or makeparticipation in the study inappropriate.