Application of 68GA-labeled CD73 Targeting Probe PET/CT Imaging in the Diagnosis of Malignant Tumor

Last updated: July 31, 2025
Sponsor: Peking Union Medical College Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Neoplasms

Treatment

68GA-DOTA-dPNE

Clinical Study ID

NCT06844110
PUMCH-NM-CD73-2
  • Ages 18-70
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

68Ga-DOTA-dPNE PET/CT imaging was performed on patients with malignant tumors to observe the binding of lesions with the tracer and evaluate the expression of CD73. At the same time, correlation analysis was performed combined with relevant clinical indicators to evaluate the efficacy of 68Ga-DOTA-dPNE in the diagnosis and guidance of malignant tumor patients, and predict the response of targeted therapy.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • 1: Age: ≥18 years, expected survival ≥12 weeks 2: Without radiotherapy andchemotherapy, surgery or biopsy is feasible to obtain pathological diagnosis 3:Standard Solid Tumor Response Evaluation Criteria (RECIST) version 1.1 with at leastone measurable target lesion 4: Obtain written informed consent and be able tofollow up

Exclusion

Exclusion Criteria:

  • 1: Severe liver and kidney dysfunction. 2: Women who are planning to conceive,pregnant, or breastfeeding, as well as those planning to have children during thestudy period, are not eligible to participate in this research. Women ofchildbearing potential must use effective contraception throughout the course of thestudy.

3: Individuals unable to lie flat for thirty minutes. 4: Suffers from claustrophobia or other mental illnesses 5: Researchers believe that the subject has other conditions that make them unsuitable for inclusion in this study 6: Refuses to join this clinical study

Study Design

Total Participants: 50
Treatment Group(s): 1
Primary Treatment: 68GA-DOTA-dPNE
Phase:
Study Start date:
March 01, 2025
Estimated Completion Date:
March 30, 2026

Connect with a study center

  • PUMCH

    Dongcheng, Beijing 100730
    China

    Active - Recruiting

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