MOTION Clinical Trial

Last updated: January 9, 2026
Sponsor: Moximed
Overall Status: Active - Recruiting

Phase

N/A

Condition

Osteoarthritis

Treatment

Non-Surgical Treatment

MISHA Knee System

Clinical Study ID

NCT06843980
CP0011
  • All Genders

Study Summary

Prospective, multicenter, two-arm, 2:1 randomized controlled trial (RCT) comparing the benefits in subjects with medial knee osteoarthritis who are treated with either the MISHA Knee System or with non-surgical treatment.

This is the first randomized head-to-head study comparing outcomes from subjects treated with the MISHA Knee System.

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

  1. Activity exacerbated knee pain isolated to the medial compartment and not global innature

  2. WOMAC pain ≥ 40

  3. Failed to find relief in non-surgical treatment modalities

Exclusion

Key Exclusion Criteria:

  1. Large medial osteophyte(s) or considerable extruded meniscus that may interfere withthe placement or function of the device

  2. Poor bone quality (e.g., bony erosion, osteopenia, osteoporosis)

  3. Ligamentous instability

  4. Active or recent knee infection

  5. Inflammatory joint disease, including sequelae of viral infections

  6. Suspected or documented allergy or hypersensitivity to cobalt, chromium, nickel orother metals

  7. History of keloid, hypertrophic or contracture scaring

  8. Propensity for restrictive scar formation or adhesions with prior procedures

Study Design

Total Participants: 100
Treatment Group(s): 2
Primary Treatment: Non-Surgical Treatment
Phase:
Study Start date:
February 13, 2025
Estimated Completion Date:
June 30, 2030

Connect with a study center

  • UC Davis Department of Orthopaedic Surgery

    Davis, California 95816
    United States

    Site Not Available

  • Scripps Clinic Jefferson

    Oceanside, California 92054
    United States

    Site Not Available

  • UC Davis Department of Orthopaedic Surgery

    Davis 5341704, California 5332921 95816
    United States

    Active - Recruiting

  • Scripps Clinic Jefferson

    Oceanside 5378771, California 5332921 92054
    United States

    Active - Recruiting

  • Rush University Medical Center

    Chicago, Illinois 60612
    United States

    Site Not Available

  • Rush University Medical Center

    Chicago 4887398, Illinois 4896861 60612
    United States

    Active - Recruiting

  • Genesis Orthopedics & Sports Medicine

    Oak Brook 4904277, Illinois 4896861 60523
    United States

    Active - Recruiting

  • University of Nebraska Medical Center

    Omaha, Nebraska 68198
    United States

    Site Not Available

  • University of Nebraska Medical Center

    Omaha 5074472, Nebraska 5073708 68198
    United States

    Active - Recruiting

  • NYU Langone Health

    New York, New York 10016
    United States

    Site Not Available

  • NYU Langone Health

    New York 5128581, New York 5128638 10016
    United States

    Active - Recruiting

  • Ohio State Jameson Crane Sports Medicine Institute

    Columbus, Ohio 43202
    United States

    Site Not Available

  • Ohio State Jameson Crane Sports Medicine Institute

    Columbus 4509177, Ohio 5165418 43202
    United States

    Active - Recruiting

  • UT Health San Antonio

    San Antonio, Texas 78249
    United States

    Site Not Available

  • UT Health San Antonio

    San Antonio 4726206, Texas 4736286 78249
    United States

    Active - Recruiting

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