The Effect of Nutritional Supplementation on Actinic Purpura: A Pilot Study

Inclusion Criteria:

• Male or female individuals aged ≥ 55 years old.

• Self-reported having actinic purpura lesions at the time of enrollment or a historyof actinic purpura lesions.

• Self-reported not using prescription or over-the-counter products that containaluminum, iron, proton pump inhibitors (PPIs), and/or topical retinol (used locallyin areas of bruising).

• If on a chronic medication that does not result in exclusion, participant mustself-report being on a stable dose for the last 3 months prior to the start of thetrial.

• Able and willing to read and voluntarily sign the study Informed Consent Form (ICF).

• Able and willing to comply with study protocol and all study-related guidelines.

• Not concomitantly participating in a study involving nutritional products.

Exclusion Criteria:

• Not complying with the study protocol.

• Having a known allergy or intolerance to nuts, seeds, fruits, vegetables, oils, andfish.

• Having a known allergy, intolerance, or dietary restriction to any of the studyingredients (Vitamin C, organic buckwheat (aerial parts) juice powder, organicbuckwheat flour, bovine adrenal Cytosol™ extract, oat flour, honey, ascorbic acid,and calcium stearate).

• Having a clinically significant condition that is severe, progressive, oruncontrolled and would compromise the study or their well-being or would prevent theparticipant from meeting or performing study requirements. This includes but is notlimited to dysphagia (or difficulty swallowing), liver or kidney disease, bonemarrow problems, Ehlers-Danlos syndrome, lupus, alcohol misuse, cancer, or HIV andother infections.

• Having active dermatological conditions. Patients with active, severe skinconditions that might interfere with the study's conduct or outcomes includingwidespread psoriasis, untreated chronic skin ulcers, or other severe dermatologicaldisorders.