An Open-Label Pilot Study of VTX2735 in Recurrent Pericarditis

Inclusion Criteria:

• Participants are male or female ≥ 18 years up to ≤ 75 years of age.

• Capable of giving signed informed consent and able to comply with the protocol

• Previously had an index (first) episode of pericarditis which met the criteria foran acute pericarditis event

• Ongoing symptomatic episode of pericarditis, or may have an episode of recurrentpericarditis in the next 4 weeks.

• CRP by local laboratory assessment prior to first dose of study treatment (participants with CRP ≤ 1 mg/dL must be receiving corticosteroid treatment for RPand have evidence of pericardial inflammation)

• Pericarditis pain score ≥ 4 based on the 11-point NRS.

• Stable doses of NSAIDs, colchicine, and/or oral corticosteroids (if receiving thesetreatments)

Exclusion Criteria:

• Current or prior diagnosis of pericarditis that is secondary to specific prohibitedcauses, including but not limited to tuberculosis, blunt trauma, tumor, myocarditis,or systemic autoimmune diseases.

• History of clinically significant immunosuppressive disorder,autoimmune/autoinflammatory disorder, or primary or secondary immunodeficiency.

• Clinically important history of a medical disorder that would compromise safety ordata quality, per the Investigator's judgment.