Adding Amantadine to Pregabalin on Occurrence of Post-thoracotomy Pain Syndrome

Last updated: February 13, 2025
Sponsor: Cairo University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Somatoform And Dissociative Disorders

Mood Disorders

Treatment

Amantadine+ Pregabalin

Pregabalin

Clinical Study ID

NCT06833203
AP2310-201-002
  • Ages 18-65
  • All Genders

Study Summary

This study aims to evaluate the additive effect of Amantadine to Pregabaline in the development of post-thoracotomy pain syndrome.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age (18-65) years.

  • Both sexes.

  • American Society of Anesthesiologists (ASA) Physical status II, III.

  • Body mass index (BMI): (20-40) kg/m2.

  • Cancer patients undergoing posterolateral thoracotomy incision for cancer lung,mesothelioma or other lung resection procedures.

Exclusion

Exclusion Criteria:

  • Patients with known sensitivity or contraindication to drug used in the study.

  • History of psychological disorders and/or chronic pain and drug abuse patients.

  • Previous administration of antidepressants, anticonvulsants, or opioids beforesurgery.

  • Patient refusal.

  • Severe respiratory or cardiac disorders.

  • Advanced liver or kidney disease.

Study Design

Total Participants: 60
Treatment Group(s): 2
Primary Treatment: Amantadine+ Pregabalin
Phase:
Study Start date:
December 01, 2023
Estimated Completion Date:
May 01, 2025

Study Description

Lung cancer is still the most common cause of cancer-related deaths, and lung resection surgeries could be the primary therapeutic option. Hence, the number of thoracotomy procedures is progressively increasing, as well as the development of post-thoracotomy pain syndrome (PTPS).

Pregabalin is one of the drugs that can reduce the excitability of the dorsal horn neurons. It is a γ-aminobutyric acid analogue that binds to α2-δ subunits of the voltage-gated calcium channels in the central nervous system.

Amantadine (1-aminoadamantane) is NMDA receptor antagonists. NMDA receptors were found to have role in the development of central sensitization, acute opioid tolerance, and opioid induced hyperalgesia.

Connect with a study center

  • Cairo University

    Cairo, 12613
    Egypt

    Active - Recruiting

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