A Phase 2 Study of MZE829 in Adults with APOL1 Kidney Disease

Last updated: February 12, 2025
Sponsor: Maze Therapeutics
Overall Status: Active - Recruiting

Phase

2

Condition

N/A

Treatment

MZE829

Clinical Study ID

NCT06830629
MZE829-201
  • Ages 18-65
  • All Genders

Study Summary

This is purpose of this study is to evaluate the safety, tolerability, and effect on Albuminuria of MZE829 in Adults with APOL1 Kidney Disease

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

  • APOL1 high risk genotype of G1/G1, G2/G2, or G1/G2

  • Chronic kidney disease with persistent albuminuria

Exclusion

Key Exclusion Criteria:

  • Organ or bone marrow transplantation

  • History of cancer within past 2 years, excepted for treated non-melanoma skincancer, stage 0 cervical cancer, or stage 1 prostate cancer

  • Conditions that may alter drug absorption, e.g., history of bariatric surgery

  • Type I diabetes

  • Pregnant or currently nursing

Other inclusion/exclusion criteria defined in protocol apply.

Study Design

Total Participants: 56
Treatment Group(s): 1
Primary Treatment: MZE829
Phase: 2
Study Start date:
February 05, 2025
Estimated Completion Date:
September 30, 2026

Study Description

An open-label Phase 2 study is designed to evaluate the safety, tolerability, and effect on Albuminuria of MZE829 in Adults with Proteinuric Chronic Kidney Disease and the APOL1 High Risk Genotype.

Connect with a study center

  • Virginia Nephrology Group

    Arlington, Virginia 22205
    United States

    Active - Recruiting

    5.8 miles

  • Clinical Renal Associates

    Upland, Pennsylvania 19013
    United States

    Active - Recruiting

    110.4 miles

  • Carolina Kidney Associates, P.A.

    Greensboro, North Carolina 27405
    United States

    Active - Recruiting

    242.35 miles

  • CN Clinical Research, LLC

    Spartanburg, South Carolina 29306
    United States

    Active - Recruiting

    386.22 miles

  • St. Clair Nephrology Research

    Shelby Township, Michigan 48315
    United States

    Active - Recruiting

    406.81 miles

  • Aa Mrc Mhs

    Flint, Michigan 48503
    United States

    Active - Recruiting

    448.9 miles

  • Primeway Clinical Research Group

    College Park, Georgia 30349
    United States

    Active - Recruiting

    553.46 miles

  • Research by Design, LLC

    Chicago, Illinois 60643
    United States

    Active - Recruiting

    592.42 miles

  • Apogee Clinical Research

    Huntsville, Alabama 35805
    United States

    Active - Recruiting

    603.63 miles

  • Florida Kidney Physicians

    Jacksonville, Florida 32250
    United States

    Active - Recruiting

    644.79 miles

  • Clinical Research of Brandon, LLC

    Brandon, Florida 33511
    United States

    Active - Recruiting

    816.69 miles

  • Florida Kidney Physicians

    Riverview, Florida 33578
    United States

    Active - Recruiting

    820.95 miles

  • SKY Integrative Medical Center

    Ridgeland, Mississippi 39157
    United States

    Active - Recruiting

    860.76 miles

  • Florida Kidney Physicians

    Fort Lauderdale, Florida 33316
    United States

    Active - Recruiting

    901.76 miles

  • San Marcus Research Clinic, Inc.

    Miami Lakes, Florida 33014
    United States

    Active - Recruiting

    917.14 miles

  • Prime Health and Wellness

    Fayette, Mississippi 39069
    United States

    Active - Recruiting

    932.17 miles

  • Renal Specialist

    Houston, Texas 77030
    United States

    Active - Recruiting

    1,222.05 miles

  • AB Clinical Trials

    Las Vegas, Nevada 89119
    United States

    Active - Recruiting

    2,083.3 miles

  • Amicis Research Center

    Palmdale, California 93551
    United States

    Active - Recruiting

    2,280.52 miles

  • Amicis Research Center

    Granada Hills, California 91344
    United States

    Active - Recruiting

    2,302.61 miles

  • Amicis Research Center

    Valencia, California 91355
    United States

    Active - Recruiting

    2,303.69 miles

  • Amicis Research Center

    Fairfield, California 94534
    United States

    Active - Recruiting

    2,410.86 miles

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