A Phase 2 Study of MZE829 in Adults With APOL1 Kidney Disease

Last updated: April 16, 2026
Sponsor: Maze Therapeutics
Overall Status: Active - Recruiting

Phase

2

Condition

N/A

Treatment

MZE829

Clinical Study ID

NCT06830629
MZE829-201
  • Ages 18-68
  • All Genders

Study Summary

This is purpose of this study is to evaluate the safety, tolerability, and effect on Albuminuria of MZE829 in Adults with APOL1 Kidney Disease

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

  • APOL1 high risk genotype of G1/G1, G2/G2, or G1/G2

  • Chronic kidney disease with persistent albuminuria

Exclusion

Key Exclusion Criteria:

  • Organ or bone marrow transplantation

  • History of cancer within past 2 years, excepted for treated non-melanoma skincancer, stage 0 cervical cancer, or stage 1 prostate cancer

  • Conditions that may alter drug absorption, e.g., history of bariatric surgery

  • Type I diabetes

  • Pregnant or currently nursing

Other inclusion/exclusion criteria defined in protocol apply.

Study Design

Total Participants: 56
Treatment Group(s): 1
Primary Treatment: MZE829
Phase: 2
Study Start date:
February 05, 2025
Estimated Completion Date:
September 30, 2026

Study Description

An open-label Phase 2 study is designed to evaluate the safety, tolerability, and effect on Albuminuria of MZE829 in Adults with Proteinuric Chronic Kidney Disease and the APOL1 High Risk Genotype.

Connect with a study center

  • Research Site

    Créteil, 94010
    France

    Active - Recruiting

  • Research Site

    Créteil 3022530, 94010
    France

    Site Not Available

  • Research Site

    Lyon, 69347
    France

    Active - Recruiting

  • Research Site

    Lyon 2996944, 69347
    France

    Site Not Available

  • Research Site

    Paris, 75015
    France

    Active - Recruiting

  • Research Site

    Paris 2988507, 75015
    France

    Site Not Available

  • Research Site

    Saint-Ouen, 93400
    France

    Active - Recruiting

  • Research Site

    Saint-Ouen 2977824, 93400
    France

    Site Not Available

  • Research Site

    Leicester, LE5 4PW
    United Kingdom

    Active - Recruiting

  • Research Site

    Leicester 2644668, LE5 4PW
    United Kingdom

    Site Not Available

  • Research Site

    London, SE19RT
    United Kingdom

    Active - Recruiting

  • Research Site

    London 2643743, SE19RT
    United Kingdom

    Site Not Available

  • Research Site

    Decatur, Alabama 35601
    United States

    Active - Recruiting

  • Apogee Clinical Research

    Huntsville, Alabama 35805
    United States

    Site Not Available

  • Research Site

    Huntsville, Alabama 35805
    United States

    Active - Recruiting

  • Research Site

    Montgomery, Alabama 36106
    United States

    Active - Recruiting

  • Research Site

    Decatur 4058553, Alabama 4829764 35601
    United States

    Site Not Available

  • Research Site

    Huntsville 4068590, Alabama 4829764 35805
    United States

    Site Not Available

  • Research Site

    Montgomery 4076784, Alabama 4829764 36117
    United States

    Site Not Available

  • Amicis Research Center

    Fairfield, California 94534
    United States

    Site Not Available

  • Amicis Research Center

    Granada Hills, California 91344
    United States

    Site Not Available

  • Research Site

    Granada Hills, California 91344
    United States

    Active - Recruiting

  • Amicis Research Center

    Palmdale, California 93551
    United States

    Site Not Available

  • Amicis Research Center

    Valencia, California 91355
    United States

    Site Not Available

  • Research Site

    Granada Hills 5353433, California 5332921 91344
    United States

    Site Not Available

  • Research Site

    Palmdale 5380698, California 5332921 93551
    United States

    Site Not Available

  • Research Site

    Valencia 5405288, California 5332921 91355
    United States

    Site Not Available

  • Research Site

    Bloomfield, Connecticut 06112
    United States

    Active - Recruiting

  • Research Site

    Bloomfield 5282526, Connecticut 4831725 06112
    United States

    Site Not Available

  • Research Site

    Atlantis, Florida 33462
    United States

    Active - Recruiting

  • Clinical Research of Brandon, LLC

    Brandon, Florida 33511
    United States

    Site Not Available

  • Research Site

    Brandon, Florida 33511
    United States

    Active - Recruiting

  • Research Site

    Brooksville, Florida 34613
    United States

    Active - Recruiting

  • Florida Kidney Physicians

    Fort Lauderdale, Florida 33316
    United States

    Site Not Available

  • Research Site

    Hollywood, Florida 33024
    United States

    Active - Recruiting

  • Florida Kidney Physicians

    Jacksonville, Florida 32250
    United States

    Site Not Available

  • Research Site

    Melbourne, Florida 32901
    United States

    Active - Recruiting

  • Research Site

    Miami Lakes, Florida 33014
    United States

    Active - Recruiting

  • San Marcus Research Clinic, Inc.

    Miami Lakes, Florida 33014
    United States

    Site Not Available

  • Research Site

    Orlando, Florida 32822
    United States

    Active - Recruiting

  • Florida Kidney Physicians

    Riverview, Florida 33578
    United States

    Site Not Available

  • Research Site

    Atlantis 4146372, Florida 4155751 33462
    United States

    Site Not Available

  • Research Site

    Brandon 4148757, Florida 4155751 33511
    United States

    Site Not Available

  • Research Site

    Brooksville 4148986, Florida 4155751 34613
    United States

    Site Not Available

  • Research Site

    Hollywood 4158928, Florida 4155751 33024
    United States

    Site Not Available

  • Research Site

    Melbourne 4163971, Florida 4155751 32901
    United States

    Site Not Available

  • Research Site

    Miami Lakes 4164186, Florida 4155751 33014
    United States

    Site Not Available

  • Research Site

    Orlando 4167147, Florida 4155751 32822
    United States

    Site Not Available

  • Research Site

    Atlanta, Georgia 30309
    United States

    Active - Recruiting

  • Primeway Clinical Research Group

    College Park, Georgia 30349
    United States

    Site Not Available

  • Research Site

    College Park, Georgia 30349
    United States

    Active - Recruiting

  • Research Site

    Cordele, Georgia 31015
    United States

    Active - Recruiting

  • Research Site

    Lithia Springs, Georgia 30122
    United States

    Active - Recruiting

  • Research Site

    Macon, Georgia 31210
    United States

    Active - Recruiting

  • Research Site

    Riverdale, Georgia 30274
    United States

    Active - Recruiting

  • Research Site

    Savannah, Georgia 31406
    United States

    Active - Recruiting

  • Research Site

    Snellville, Georgia 30078
    United States

    Active - Recruiting

  • Research Site

    College Park 4188815, Georgia 4197000 30349
    United States

    Site Not Available

  • Research Site

    Cordele 4189423, Georgia 4197000 31015
    United States

    Site Not Available

  • Research Site

    Macon 4207400, Georgia 4197000 31210
    United States

    Site Not Available

  • Research Site

    Riverdale 4219001, Georgia 4197000 30274
    United States

    Site Not Available

  • Research Site

    Savannah 4221552, Georgia 4197000 31406
    United States

    Site Not Available

  • Research Site

    Chicago, Illinois 60616
    United States

    Active - Recruiting

  • Research by Design, LLC

    Chicago, Illinois 60643
    United States

    Site Not Available

  • Research Site

    Chicago 4887398, Illinois 4896861 60643
    United States

    Site Not Available

  • Research Site

    Kansas City, Kansas 66112
    United States

    Active - Recruiting

  • Research Site

    Kansas City 4273837, Kansas 4273857 66112
    United States

    Site Not Available

  • Research Site

    Bowling Green, Kentucky 42101
    United States

    Active - Recruiting

  • Research Site

    Louisville, Kentucky 40205
    United States

    Active - Recruiting

  • Research Site

    Bowling Green 4285268, Kentucky 6254925 42101
    United States

    Site Not Available

  • Research Site

    Louisville 4299276, Kentucky 6254925 40205
    United States

    Site Not Available

  • Research Site

    Arnold, Maryland 21012
    United States

    Active - Recruiting

  • Research Site

    Lutherville, Maryland 21093
    United States

    Active - Recruiting

  • Research Site

    Oxon Hill, Maryland 20745
    United States

    Active - Recruiting

  • Research Site

    Arnold 4347426, Maryland 4361885 21012
    United States

    Site Not Available

  • Research Site

    Baltimore 4347778, Maryland 4361885 21213
    United States

    Site Not Available

  • Research Site

    Lutherville 4361379, Maryland 4361885 21093
    United States

    Site Not Available

  • Research Site

    Oxon Hill 4364759, Maryland 4361885 20745
    United States

    Site Not Available

  • Research Site

    Dearborn, Michigan 48126
    United States

    Active - Recruiting

  • Aa Mrc Mhs

    Flint, Michigan 48503
    United States

    Site Not Available

  • Research Site

    Flint, Michigan 48503
    United States

    Active - Recruiting

  • Research Site

    Pontiac, Michigan 48341
    United States

    Active - Recruiting

  • Research Site

    Saint Joseph, Michigan 49085
    United States

    Active - Recruiting

  • St. Clair Nephrology Research

    Shelby Township, Michigan 48315
    United States

    Site Not Available

  • Research Site

    Dearborn 4990510, Michigan 5001836 48126
    United States

    Site Not Available

  • Research Site

    Flint 4992982, Michigan 5001836 48503
    United States

    Site Not Available

  • Research Site

    Pontiac 5006166, Michigan 5001836 48341
    United States

    Site Not Available

  • Research Site

    Saint Joseph 5008327, Michigan 5001836 49085
    United States

    Site Not Available

  • Research Site

    Shelby 5009586, Michigan 5001836 48092
    United States

    Site Not Available

  • Research Site

    Minneapolis, Minnesota 55404
    United States

    Active - Recruiting

  • Research Site

    Minneapolis 5037649, Minnesota 5037779 55404
    United States

    Site Not Available

  • Prime Health and Wellness

    Fayette, Mississippi 39069
    United States

    Site Not Available

  • SKY Integrative Medical Center

    Ridgeland, Mississippi 39157
    United States

    Site Not Available

  • Research Site

    Tupelo, Mississippi 38801
    United States

    Active - Recruiting

  • Research Site

    Fayette 4426218, Mississippi 4436296 39069
    United States

    Site Not Available

  • Research Site

    Ridgeland 4443296, Mississippi 4436296 39157
    United States

    Site Not Available

  • Research Site

    Tupelo 4448903, Mississippi 4436296 38801
    United States

    Site Not Available

  • Research Site

    City of Saint Peters, Missouri 63376
    United States

    Active - Recruiting

  • Research Site

    St Louis, Missouri 63103
    United States

    Active - Recruiting

  • Research Site

    City of Saint Peters 4407237, Missouri 4398678 63376
    United States

    Site Not Available

  • Research Site

    St Louis 4407066, Missouri 4398678 63103
    United States

    Site Not Available

  • AB Clinical Trials

    Las Vegas, Nevada 89119
    United States

    Site Not Available

  • Research Site

    Las Vegas, Nevada 89107
    United States

    Active - Recruiting

  • Research Site

    Las Vegas 5506956, Nevada 5509151 89107
    United States

    Site Not Available

  • Research Site

    Buffalo, New York 14203
    United States

    Active - Recruiting

  • Research Site

    Laurelton, New York 11413
    United States

    Active - Recruiting

  • Research Site

    Maspeth, New York 11378
    United States

    Active - Recruiting

  • Research Site

    New York, New York 10021
    United States

    Active - Recruiting

  • Research Site

    Newburgh, New York 12550
    United States

    Active - Recruiting

  • Research Site

    Laurelton 5124078, New York 5128638 11413
    United States

    Site Not Available

  • Research Site

    Maspeth 5126180, New York 5128638 11378
    United States

    Site Not Available

  • Research Site

    New York 5128581, New York 5128638 10021
    United States

    Site Not Available

  • Research Site

    Durham, North Carolina 27708
    United States

    Active - Recruiting

  • Research Site

    Fayetteville, North Carolina 28304
    United States

    Active - Recruiting

  • Carolina Kidney Associates, P.A.

    Greensboro, North Carolina 27405
    United States

    Site Not Available

  • Research Site

    Greensboro, North Carolina 27405
    United States

    Active - Recruiting

  • Research Site

    Shelby, North Carolina 28150
    United States

    Active - Recruiting

  • Research Site

    Durham 4464368, North Carolina 4482348 27708
    United States

    Site Not Available

  • Research Site

    Fayetteville 4466033, North Carolina 4482348 28304
    United States

    Site Not Available

  • Research Site

    Greensboro 4469146, North Carolina 4482348 27405
    United States

    Site Not Available

  • Research Site

    Shelby 4491180, North Carolina 4482348 28150
    United States

    Site Not Available

  • Research Site

    Cincinnati, Ohio 45267
    United States

    Active - Recruiting

  • Research Site

    Cleveland, Ohio 44195
    United States

    Active - Recruiting

  • Research Site

    Columbus, Ohio 43215
    United States

    Active - Recruiting

  • Research Site

    Cincinnati 4508722, Ohio 5165418 45267
    United States

    Site Not Available

  • Research Site

    Cleveland 5150529, Ohio 5165418 44106
    United States

    Site Not Available

  • Research Site

    Columbus 4509177, Ohio 5165418 43215
    United States

    Site Not Available

  • Research Site

    Ardmore, Oklahoma 73401
    United States

    Active - Recruiting

  • Research Site

    Ardmore 4529469, Oklahoma 4544379 73401
    United States

    Site Not Available

  • Research Site

    Philadelphia, Pennsylvania 19104
    United States

    Active - Recruiting

  • Clinical Renal Associates

    Upland, Pennsylvania 19013
    United States

    Site Not Available

  • Research Site

    Upland, Pennsylvania 19013
    United States

    Active - Recruiting

  • Clinical Renal Associates

    Upland 4561874, Pennsylvania 6254927 19013
    United States

    Active - Recruiting

  • Research Site

    Upland 4561874, Pennsylvania 6254927 19013
    United States

    Site Not Available

  • Research Site

    Columbia, South Carolina 29203
    United States

    Active - Recruiting

  • CN Clinical Research, LLC

    Spartanburg, South Carolina 29306
    United States

    Site Not Available

  • Research Site

    Spartanburg, South Carolina 29302
    United States

    Active - Recruiting

  • Research Site

    Columbia 4575352, South Carolina 4597040 29203
    United States

    Site Not Available

  • Research Site

    Spartanburg 4597200, South Carolina 4597040 29302
    United States

    Site Not Available

  • Research Site

    Chattanooga, Tennessee 37404
    United States

    Active - Recruiting

  • Research Site

    Chattanooga 4612862, Tennessee 4662168 37404
    United States

    Site Not Available

  • Research Site

    Dallas, Texas 75230
    United States

    Active - Recruiting

  • Research Site

    Greenville, Texas 75402
    United States

    Active - Recruiting

  • Renal Specialist

    Houston, Texas 77030
    United States

    Site Not Available

  • Research Site

    Houston, Texas 77099
    United States

    Active - Recruiting

  • Research Site

    McKinney, Texas 75069
    United States

    Active - Recruiting

  • Research Site

    San Antonio, Texas 78251
    United States

    Active - Recruiting

  • Research Site

    Shenandoah, Texas 77384
    United States

    Active - Recruiting

  • Research Site

    Sherman, Texas 75092
    United States

    Active - Recruiting

  • Research Site

    Dallas 4684888, Texas 4736286 75230
    United States

    Site Not Available

  • Research Site

    Greenville 4695066, Texas 4736286 75402
    United States

    Site Not Available

  • Research Site

    Houston 4699066, Texas 4736286 77030
    United States

    Site Not Available

  • Research Site

    Katy 4702732, Texas 4736286 77450
    United States

    Site Not Available

  • Research Site

    McKinney 4710178, Texas 4736286 75069
    United States

    Site Not Available

  • Research Site

    San Antonio 4726206, Texas 4736286 78251
    United States

    Site Not Available

  • Research Site

    Shenandoah 4728287, Texas 4736286 77384
    United States

    Site Not Available

  • Research Site

    Sherman 4728328, Texas 4736286 75092
    United States

    Site Not Available

  • Virginia Nephrology Group

    Arlington, Virginia 22205
    United States

    Site Not Available

  • Research Site

    Norfolk, Virginia 23504
    United States

    Active - Recruiting

  • Research Site

    Hampton 4762894, Virginia 6254928 23666
    United States

    Site Not Available

  • Research Site

    Norfolk 4776222, Virginia 6254928 23504
    United States

    Site Not Available

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