Intravenous Methadone Versus Intrathecal Morphine for Analgesia Following Cesarean Delivery

Inclusion Criteria:

• English-speaking

• Age over 18 years old

• Scheduled cesarean delivery

Exclusion Criteria:

• Any contraindication to the administration of a spinal technique for anesthesia

• History of intolerance or adverse reaction to opioid medications

• History of chronic pain, opioid use >30 OME/day, or substance use disorder

• History of obstructive sleep apnea, chronic obstructive pulmonary disease, orrespiratory compromise (SpO2 <92% on room air, or has a pre-existing oxygenrequirement)

• History of liver or kidney failure

• Diagnosis of pre-eclampsia with current pregnancy

• Depression requiring more than one medication

• Planned use of CSE technique

• BMI >50.0 kg/m2

• ASA status IV, V

• No prior history of an ECG demonstrating QTc > 440ms

• Surgical complication requiring conversion to general anesthesia