Prediction of Risk of Vascular Structural Damage in Patients with Large Vessel Vasculitis (LVV) Based on PET/MRA Image Evaluation System

Last updated: February 7, 2025
Sponsor: Nanjing Medical University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Vascular Diseases

Dermatomyositis (Connective Tissue Disease)

Lupus

Treatment

glucocorticoid, immunosuppressants, targeted therapy

Clinical Study ID

NCT06824714
2024-SR-693
  • Ages > 18
  • All Genders

Study Summary

Large vessel vasculitis (LVV) causes vascular inflammation, leading to serious complications such as aneurysm formation and stroke. It is difficult to identify the inflammation of the vessel wall by the current imaging methods, thus affecting the timing of treatment and selection of treatment options. Improved examination methods to determine disease activity are highly needed to guide treatment.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Clinically suspected or confirmed LVV and willing to undergo PET/MRA

  2. Compliance with long-term follow-up

  3. Sign informed consent.

Exclusion

Exclusion Criteria:

  1. Patients with other serious cardiovascular and cerebrovascular diseases, malignanttumors, infectious diseases, severe renal insufficiency.

  2. Severe mental disorders, severe claustrophobia unable to cooperate with theexamination.

  3. Patients equipped with cardiac pacemaker, artificial heart valve, ferromagneticvascular clamp after vascular surgery, aneurysm clamp, artificial cochlea, insulinpump and other drug dosage control devices, steel nail plate and other metalinternal fixation, artificial joint, electronic eye, artificial eye.

  4. Allergic to contrast medium.

  5. Pregnant or lactating women.

Withdrawal criteria:

  1. Any exclusion criteria emerged during patient follow-up.

  2. Voluntarily withdrew from the study.

Study Design

Total Participants: 150
Treatment Group(s): 1
Primary Treatment: glucocorticoid, immunosuppressants, targeted therapy
Phase:
Study Start date:
January 01, 2024
Estimated Completion Date:
July 01, 2028

Study Description

This study was designed to assess vascular wall inflammation in patients with large vessel vasculitis by positron emission tomography and magnetic resonance imaging (PET/MRA). The study has a 12-month follow-up period. After completing the baseline clinical assessment, laboratory test and PET/MRA assessment, the intervention protocol will be determined by clinicians. The patients will visit the clinic every 1-2 months according to their specific conditions. Clinical assessment, laboratory test and PET/MRA re-examination will be completed at 6 and 12 months after treatment.

Connect with a study center

  • Department of Rheumatology and Immunology, Jiangsu Province Hospital, Nanjing Medical University

    Nanjing, Jiangsu 210029
    China

    Active - Recruiting

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