Hemodynamic Determinants of Urine Output During Spinal Anesthesia

Last updated: April 5, 2025
Sponsor: Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Marcaine 0.5% Solution for Injection

Clinical Study ID

NCT06814561
2511
  • Ages > 18
  • All Genders

Study Summary

This clinical trial investigates the relationship between urine output and mean arterial pressure (MAP) during spinal anesthesia. The study aims to validate observations from animal models in humans by concurrently measuring hemoglobin levels, MAP, and urine output, focusing on the effects of Ringer's solution, to provide crucial insights into optimal fluid management during anesthesia with minimal complexity.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Written informed consent provided by patients or their legally authorizedrepresentatives.

  • Adults aged 18 years and older.

Exclusion

Exclusion Criteria:

  • Contraindications to Spinal Anesthesia:

  • Patient refusal

  • Presence of coagulopathy.

  • Current use of anticoagulant or antiplatelet medications.

  • Critical or severe aortic stenosis or other fixed cardiac output states.

  • High risk of infection at the spinal needle insertion site.

  • Elevated intracranial pressure.

  • Allergy

  • Sepsis

  • Procedures Not Amenable to Spinal Anesthesia:

  • Planned concurrent procedures that cannot be performed under spinal anesthesia.

Study Design

Total Participants: 20
Treatment Group(s): 1
Primary Treatment: Marcaine 0.5% Solution for Injection
Phase:
Study Start date:
January 30, 2025
Estimated Completion Date:
April 30, 2025

Study Description

The proposed clinical trial aims to explore the relationship between urine output and mean arterial pressure (MAP) during spinal anesthesia, a subject that has not been thoroughly studied in humans despite previous research under general anesthesia. Studies have demonstrated that the diuretic response to intravenous volume loading, using Ringer's solution or 20% albumin, varies with MAP levels. Specifically, Ringer's solution shows a greater diuretic effect when MAP exceeds 70 mmHg, whereas 20% albumin is more effective at lower pressures. This differential response highlights the importance of considering MAP in the choice of fluid for managing hypovolemia and oliguria.

The study's relevance is highlighted by the physiological dynamics at play, particularly how high levels of anesthesia, which influence the sympathetic nervous system from the mid-thoracic region, might reduce MAP and consequently decrease urine output. While this hypothesis has been examined in animal studies, its validity in humans remains unconfirmed.

To address this, the trial will measure hemoglobin levels, MAP, and urine output simultaneously, aiming to establish a clear correlation among these variables during spinal anesthesia. This methodical approach seeks to yield significant insights with minimal additional effort, contrasting with the complexities inherent in more elaborate study designs.

Connect with a study center

  • "Prof CC Iliescu" Emergency Institue for Cardiovascular Diseases

    Bucharest, 022328
    Romania

    Active - Recruiting

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