Left Ventricular Reverse Remodeling Evaluation After Surgical Correction of Aortic Regurgitation

Last updated: June 5, 2025
Sponsor: Petrovsky National Research Centre of Surgery
Overall Status: Active - Recruiting

Phase

N/A

Condition

Chest Pain

Congestive Heart Failure

Mitral Valve Regurgitation

Treatment

Not applicable - observational study

Clinical Study ID

NCT06805253
173538086
  • Ages > 18
  • All Genders

Study Summary

Investigators assume that surgical correction approach to functional mitral regurgitation during intervention for chronic aortic regurgitation in patients with severe enlargement of the left heart chambers influences reverse remodeling of the left ventricle (LV) in the postoperative period. It is suggested that functional mitral regurgitation (MR) provides supra-physiological left ventricle volume overload and this fact plays positive role in early-stage post-operative left ventricle volume and function recovery. LV volume, systolic and diastolic function will be monitored with echocardiography (EchoCG) along with life quality in patients with different grades of functional mitral regurgitation secondary to severe chronic aortic insufficiency after surgical treatment of aortic regurgitation.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age over 18 years

  • Planned primary elective surgery for chronic aortic regurgitation

  • Presence of functional mitral regurgitation

  • End-diastolic volume of the left ventricle >= 250 ml

Exclusion

Exclusion Criteria:

  • Infectious endocarditis

  • History of myocardial infarction

  • Indications on simultaneous myocardial revascularisation

  • Acute aortic regurgitation of any etiology

  • Previously diagnosed dilatation of the left ventricle, not associated with thedevelopment of aortic regurgitation

  • Long-term persistent or permanent form of atrial fibrillation

  • Pregnancy in the first 12 months after surgery

  • Simultaneous participation in other studies

  • Presence of implanted pacemakers

  • Refusal to sign informed consent

  • Acute coronary event diagnosed within 12 months after aortic valve surgery

  • Indications for resynchronization therapy or permanent right ventricular pacing inthe first 12 months after aortic valve surgery

  • Re-do cardiac surgery for any reason within 12 months after aortic valve surgery

Study Design

Total Participants: 120
Treatment Group(s): 1
Primary Treatment: Not applicable - observational study
Phase:
Study Start date:
May 09, 2024
Estimated Completion Date:
May 31, 2030

Connect with a study center

  • Petrovsky National Research Center of Surgery

    Moscow, 119435
    Russian Federation

    Active - Recruiting

  • Voronezh Regional Clinical Hospital No. 1

    Voronezh, 394066
    Russian Federation

    Active - Recruiting

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