Relationship Between Aspirin Metabolism and Markers of Metabolic Dysfunction Among Pregnant Persons at Risk of Pre-eclampsia

Inclusion Criteria:

• Recommended aspirin for pre-eclampsia prevention by OB/GYN or MFM specialist basedon ACOG and USPSTF guidelines (1 high risk factor, 2+ moderate risk factors)

• Willingness to adhere to aspirin therapy

• Willingness to undergo 2h OGTT for serum and urine collection in addition tosurvey collection, indirect calorimetry, body composition measures, neonatalmeasures, etc.

• Gestational age at enrollment <16 weeks

• Ability to speak, read, and communicate via English

Exclusion Criteria:

• Type 2 Diabetes Mellitus

• Type 1 Diabetes Mellitus

• Current gestational diabetes mellitus

• Current/active platelet disorder or bleeding diathesis (thrombocytopenia of anyetiology, idiopathic thrombocytopenic purpura/ITP, thrombotic thrombocytopenicpurpura/TTP, von Willebrand disease, etc.)

• Thrombophilia

• Current use of NSAID for other indication (indomethacin, ibuprofen, etc.)

• Current use of other immune-modulating agents and biologics (hydroxychloroquine, azathioprine, 6-mercaptopurine, IL-6 inhibitors, etc.)

• Current or recent use of steroids

• Current use of prophylactic or therapeutic anticoagulation

• Medical contraindication to aspirin therapy

• Molar pregnancy

• Renal disease

• Inability or unwillingness to give informed consent

• Current psychiatric illness/social situation that would limit compliance withstudy requirements, as determined by the principal investigators