Change in Omega 3 Index in Healthy Adults with OmeGo or a Standard Omega-3 Oil Supplement

Last updated: February 18, 2025
Sponsor: Hofseth Biocare ASA
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Cod liver oil

whole salmon oil

Clinical Study ID

NCT06802068
HBC-CARDIO-2024-001-v2
  • Ages 40-80
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Omega-3 index is used as a proxy for an adequate intake of fish unsaturated fats in the diet. However, omega-3 supplements have not consistently shown the health benefits of eating fresh fish. This study will assess the change in omega-3 index and impact on markers of cardiometabolic health with two different supplements: a whole, unprocessed salmon oil and a standard, processed, concentrated oemga-3 oil. The markers to be studies included impact on inflammation and oxidative stress, cholesterol and markers of risk of diabetes. Change in sleep metrics will also be assessed.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Healthy, non-pregnant adults; 40-80 years of age; stable body weight prior 3 months

Exclusion

Exclusion Criteria:

  • Fish or seafood allergies; Pregnant; already consuming fish oil supplementation;malabsorption states; malignancy in remission for less than 12 months; diabetic

Study Design

Total Participants: 96
Treatment Group(s): 2
Primary Treatment: Cod liver oil
Phase:
Study Start date:
February 18, 2025
Estimated Completion Date:
October 01, 2025

Study Description

Omega-3 index is used as a proxy for an adequate intake of fish unsaturated fats in the diet. However, omega-3 supplements have not consistently shown the health benefits akin to eating fresh fish. This could be because contains many more fats than just EPA and DHA and these other fats have well defined health benefits such as oleic acid which is also abundant in olive oil. Alternatively this might be a result of significant processing needed to extract and concentrate the omega-3 fraction resulting in elevated levels of oxidation and free fatty acids, both of which are pro-inflammatory and would therefore impair the health benefits of omega-3. This study will assess the change in omega-3 index and impact on markers of cardiometabolic health with two different supplements: a whole, unprocessed salmon oil and a standard, processed, concentrated oemga-3 oil. The markers to be studies included impact on common drivers of inflammation and oxidative stress, blood cholesterol and markers of the risk of developing diabetes. Change in sleep metrics will also be assessed using both questionnaires and data from the hypnograms recorded by wearable device.

Connect with a study center

  • Alethios

    Menlo Park, California 94025
    United States

    Active - Recruiting

  • Alethios, Inc.

    San Francisco, California 94109
    United States

    Active - Recruiting

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