Botox for Chronic Pelvic Pain

Inclusion Criteria:

1. Females between 18 and 60 years of age

2. Clinical diagnosis of interstitial cystitis/bladder pain symptoms

3. Complaints of pain, pressure, or discomfort in the bladder and/or pelvic area forthe past 6 months or more, associated with lower urinary tract symptoms (such asfrequency of urination), in the absence of other explanation of the symptoms (e.g.,UTI) *

4. Myofascial pain diagnosed with palpable bands or nodules of contracted muscle fibers

5. Pelvic muscle tenderness by assessment of pelvic floor muscles on digital pelvicexamination

6. No botulinum neurotoxin pelvic floor muscle injection treatment within 6 monthsprior to recruitment

7. Able to provide informed consent

Exclusion Criteria:

1. Males

2. Women < 18 and > 60 years of age

3. History of pelvic malignancy and sexual transmitted diseases that is currently notin remission

4. Bleeding disorder such as coagulopathy

5. Hypersensitivity to botulinum neurotoxin

6. Received botulinum neurotoxin pelvic floor muscle injection within 6 months prior torecruitment

7. History of neurological disorders, such as spinal cord injury, multiple sclerosis,amyotrophic lateral sclerosis or myasthenia gravis

8. Pregnancy, breast feeding or planning to get pregnant within one year after the lastbotulinum neurotoxin injection.