Camrelizumab Combined with Rivoceranib and Hepatic Arterial Infusion Chemotherapy (HAIC) As Conversion Therapy for Potentially Resectable Hepatocellular Carcinoma(HCC)

Inclusion Criteria:

1. Signed Informed Consent Form (ICF)

2. Aged ≥18 years and ≤75 years at time of signing ICF

3. Documented diagnosis of HCC confirmed by histology/cytology or clinically

4. Patients with BCLC stage B (the sum of number of tumors and the maximum diameter ofthe largest tumor exceeding Up-to-7 criteria) and BCLC stage C without extrahepaticmetastasis: ① tumors confined to one lobe (left, right, or middle lobe), or tumorsin one lobe are present alongside a single tumor with diameter ≤5 cm or up to threetumors each with diameter ≤3 cm in the remaining lobes; ②No PVTT involving thecontralateral liver lobe or reaching the superior mesenteric vein. And no tumorthrombus of the inferior vena cava reaching right atrium

5. At least one measurable lesion (per RECIST v1.1) untreated lesion

6. ECOG performance status of 0 or 1

7. Child-Pugh ≤7 score

8. Life expectancy ≥12 weeks

9. Adequate organ function

10. No prior anti-tumor systemic therapies for HCC

Exclusion Criteria:

1. Known fibrolamellar HCC, sarcomatoid HCC, or mixed cholangiocarcinoma and HCC

2. Other active malignant tumor except HCC within 5 years or simultaneously

3. Prior locoregional therapy (such as TACE、TAE、HAIC、TARE)

4. There is an absolute contraindication to HAIC

5. History of hepatic encephalopathy

6. Diffuse HCC, intrahepatic tumor burden > 50%

7. PVTT reaching the superior mesenteric vein, and bilateral PVTT are present

8. Clinically significant ascites

9. Prior allogeneic stem cell or solid organ transplantation