Phase
Condition
N/ATreatment
10mg Psilocybin
5mg Psilocybin
40mg Psilocybin
Clinical Study ID
Ages 25-75 All Genders Accepts Healthy Volunteers
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Age between 25 and 75 years.
Sufficient understanding of the German language.
Understanding the procedures and the risks that are associated with the study.
Participants must be willing to adhere to the protocol and sign the consent form.
Participants must be willing to refrain from taking illicit psychoactive substancesduring the study (not including cannabis).
Participants must be willing not to drive a traffic vehicle or to operate machineswithin 48 h after substance administration.
Women of childbearing potential must be willing to use effective birth-controlthroughout study participation
Exclusion
Exclusion Criteria:
Chronic or acute medical condition, including a history of seizures.
Body mass index 18-29.9 kg/m2
Current or previous major psychiatric disorder (e.g. psychotic disorders, mania /hypomania, anxiety disorders).
Psychotic or bipolar disorder in first-degree relatives, not including psychoticdisorders secondary to an apparent medical reason, e.g., brain injury, dementia, orlesions of the brain.
Hypertension (SBP>140/90 mmHg) or hypotension (SBP<85 mmHg)
Psychedelic substance use (with the exception of cannabis) more than 20 times or anytime within the previous two months
Pregnant or nursing women.
Participation in another clinical trial (currently or within the last 30 days).
Use of medications that may interfere with the effects of the study medications (anypsychiatric medications and any medication with known to interact with the studysubstances).
Tobacco smoking (>10 cigarettes/day).
Consumption of alcoholic drinks (>15 drinks / week).
Body weight < 45 kg.
Study Design
Study Description
Connect with a study center
Clinical Trial Unit
Basel, Basel-Stadt 4056
SwitzerlandActive - Recruiting
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