Comparative Study Between HOMA1-IR and HOMA2-IR in Prediction of Ovulation Outcome in Women With PCOS

Last updated: February 3, 2025
Sponsor: Cairo University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Reproductive Health

Polycystic Ovarian Syndrome

Treatment

Aromatase inhibitor Letrozole

Clinical Study ID

NCT06793904
N 364-2024
Cairo university
  • Ages 18-35
  • Female

Study Summary

122 women diagnosed with PCOS seeking fertility in the fertility clinic at kasr Alainy hospital will be subjected to Homeostatic model assessment for insulin resistance 1 was calculated for all participants through the equation [glucose (mmol/L) × insulin (µU/L)]/22.5 while homeostatic model assessment for insulin resistance 2 was calculated by the HOMA2 calculator. All women will be subjected to induction of ovulation using the Aromatase inhibitor Letrozole 2.5 mg tab twice daily from the 3rd day of the cycle for 5 days . Ultrasound follow up of follicular growth will be performed till dominant follicular size reaches 18-22 mm. FSH preparations will be introduced as needed.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age 18-35 years

  • duration of infertility 1-4 years

  • PCOS

Exclusion

Exclusion Criteria:

women with other causes of infertility (tubal factor assessed by laparoscopy or hysterosalpingogram, uterine cavity abnormality assessed by ultrasound or hysteroscopy or male factor assessed by seme analysis),

  • endometriosis,

  • ovarian cysts,

  • endocrinological abnormalities (Diabetes mellitus, hypothalamic, pituitary orthyroid disorders, or hyperprolactinemia),

  • women with history of poor ovarian response or ovarian hyperstimulation

  • women with chronic diseases, chromosomal, autoimmune or coagulation defects,abnormal leucocytic count or other inflammatory markers

  • Women with contraindications to pregnancy.

Study Design

Total Participants: 122
Treatment Group(s): 1
Primary Treatment: Aromatase inhibitor Letrozole
Phase:
Study Start date:
February 01, 2025
Estimated Completion Date:
January 31, 2026

Connect with a study center

  • Kasr Alainy medical school

    Cairo, 12111
    Egypt

    Active - Recruiting

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